研究方向：胚胎干细胞及平滑肌细胞分化；小鼠头面部器官发育
联系电话：(0571) 28865657

电子邮件：jidewohhr@163.com

通讯地址：浙江省杭州市下沙高教园区学林街16号，310036

个人简历：

1993-1997，江西农业大学园艺系，本科

1997-2000，浙江大学生命科学学院，硕士

2000-2003，浙大天目生物技术有限公司研发部，经理

2003-2006，浙江大学生命科学学院，博士

2007-2010，美国密歇根大学心血管研究中心，博士后

2010-至今，杭州师范大学再生与发育研究所，助理、副研究员

科研项目

² 浙江省自然科学基金面上项目（主持）：P53调控血管平滑肌细胞分化及表型转换的机制研究，（LY15C070005，2015/01-2017/12），8万元。

² 杭州市科委主动设计项目（主持）：杭州市生猪产业流行疫病控制和猪肉产品生物安全监管关键技术研究与示范，（20162012A07，2016/09-2019/08），200万元。

² 国家自然科学基金青年项目（主持）：microRNA-10a在平滑肌细胞表型转换中的作用机制研究(No.31101046；2012.1～2014.12），25万元

² American Heart Association Postdoctoral Fellowship（主持）"Mechanism of nitroalkene-induced downregulation of AT1 receptor in vascular smooth muscle cells" (No. 0825837G；2008.7～2010.6) ，10万美元

论文专著

² Tan Z, Li J, Zhang X, Yang X, Zhang Z, Yin KJ, Huang H. TP53 Promotes Retinoid Acid-induced Smooth Muscle Cell Differentiation by Targeting Myocardin. Stem Cells Dev 2018.

² Huang H, Yang X, Bao M, Cao H, Miao X, Zhang X, Gan L, Qiu M, Zhang Z. Ablation of the Sox11 Gene Results in Clefting of the Secondary Palate Resembling the Pierre Robin Sequence. J Biol Chem 2016, 291(13): 7107-7118.

² Xie CQ, Ritchie RP, Huang HR, Zhang JF, Chen YE. Smooth Muscle Cell Differentiation In Vitro Models and Underlying Molecular Mechanisms. Arteriosclerosis Thrombosis and Vascular Biology 2011, 31(7): 1485-1494.

² Xie CQ, Huang HR, Sun XA, Guo YH, Hamblin M, Ritchie RP, Garcia-Barrio MT, Zhang JF, Chen YE. MicroRNA-1 Regulates Smooth Muscle Cell Differentiation by Repressing Kruppel-Like Factor 4. Stem Cells and Development 2011, 20(2): 205-210.

² Yin KJ, Deng Z, Huang HR, Hamblin M, Xie CQ, Zhang JF, Chen YE. miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia. Neurobiology of Disease 2010, 38(1): 17-26.

² Yin KJ, Deng Z, Hamblin M, Xiang Y, Huang HR, Zhang JF, Jiang XD, Wang YZ, Chen YE. Peroxisome Proliferator-Activated Receptor delta Regulation of miR-15a in Ischemia-Induced Cerebral Vascular Endothelial Injury. Journal of Neuroscience 2010, 30(18): 6398-6408.

² Yao X, Zhang JR, Huang HR, Dai LC, Liu QJ, Zhang M. Histone deacetylase inhibitor promotes differentiation of embryonic stem cells into neural cells in adherent monoculture. Chinese medical journal 2010, 123(6): 734-738.

² Tang XC, Guo YH, Nakamura K, Huang HR, Hamblin M, Chang L, Villacorta L, Yin KJ, Ouyang HS, Zhang JF. Nitroalkenes induce rat aortic smooth muscle cell apoptosis via activation of caspase-dependent pathways. Biochemical and Biophysical Research Communications 2010, 397(2): 239-244.

² Huang HR, Xie CQ, Sun X, Ritchie RP, Zhang JF, Chen YE. miR-10a Contributes to Retinoid Acid-induced Smooth Muscle Cell Differentiation. Journal of Biological Chemistry 2010, 285(13): 9383-9389.

² Xie CQ, Huang HR, Wei S, Song LS, Zhang JF, Ritchie RP, Chen LB, Zhang M, Chen YE. A Comparison of Murine Smooth Muscle Cells Generated from Embryonic versus Induced Pluripotent Stem Cells. Stem Cells and Development 2009, 18(5): 741-748.

² XIE C, ZHANG J, VILLACORTA L, CUI T, HUANG H, CHEN Y. A highly efficient method to differentiate smooth muscle cells from human embryonic stem cells. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2007, 27: E311-E312.

² Liu QJ, Huang HR, Cai H, Xu Y, Li Y, Li R, Wang P. Embryonic stem cells as a novel cell source of cell-based biosensors. Biosensors & Bioelectronics 2007, 22(6): 810-815.

² Huang HR, Zhao XL, Chen LB, Xu C, Yao X, Lu YL, Dai LC, Zhang M. Differentiation of human embryonic stem cells into smooth muscle cells in adherent monolayer culture. Biochemical and Biophysical Research Communications 2006, 351(2): 321-327.