男，1964年生，江苏苏州人，
Phone: 0571-28933086 (O)
E-mail: jianmingchen@hznu.edu.cn
地址：浙江省杭州市下沙高教园区学林街16号，杭州，310036
1983.09-1987.07 南京师范大学生物学，本科生
1992.09-1995.07 东南大学医学院，硕士研究生
1997.09-2001.08 浙江大学医学院，博士研究生
1995.08-2002.02 浙江大学医学院，助教，助研
2002.03-2003.07 美国，The Ohio State University，Research Associate
2003.08-2004.11 美国，Northwestern University，Research Associate
2004.12-2007.03 美国，Loyola University Medical Center，Research Associate
2007.09–至今 杭州师范大学生命与环境科学学院，副教授

科研项目

1 浙江省自然科学基金Y2090698（2010-2011）（主持）

IFI16基因在喉癌细胞中的作用及其分子机制研究

2 浙江省教育厅项目200803258（2009-2011）（主持）

IFI16基因在人喉鳞癌Hep-2细胞生长中的作用

3 杭州师范大学科研基金重点项目B01031201（2008-2009）（主持）

IFI16基因与人喉鳞癌的关系研究

4 杭州师范大学科研启动经费项目004031401（2008-2009）（主持）

干扰素可诱导的IFI16基因在人喉鳞癌细胞生长中的作用研究

5 美国National Institute on Aging 51R01AG025036-04 （2006-2010）（参加）

Role of IFI16 in Cellular Senescence

6 美国National Institute of Allergy and Infectious diseases 5R01AI066261-04（2005-2010）（参加）

Gender-Specific Role of p202 in Lupus Susceptibility

7 美国National Institute of Environmental Health Sciences 2R01ES002388-20（1981-2011）（参加）

DNA Damage Responses Following Genotoxin Exposure

8 国家自然科学基金面上项目30170810（2002-2004）（参加）

人hRAD30和DINB1编码的DNA聚合酶与哺乳基因突变

9 国家自然科学基金重点项目39830210（1999-2001）（参加）

化学物质诱发基因组DNA不稳定的分子机制研究

10 国家自然科学基金面上项目39870340（1999-2001）（参加）

人FEN-1基因功能及其在遗传不稳定形成中的作用研究

11 浙江省自然科学基金课题397454（1998-2000）（参加）

DNA复制保真度与致癌物诱发的遗传不稳定

12 浙江省自然科学基金课题 396054（1997-1999）（参加）

哺乳类细胞非定标性突变的信息转导机制
主要成绩


论文专著

1 赵菁, 陈建明, 邱明, 应奇才.干扰素诱导的IFI-200蛋白家族研究进展.杭州师范大学学报(自然科学版), 2009, (5): 375-380.

2 Rekha Singh, Divaker Choubey, Jianming Chen and David J. Leehey. Inhibition of intracellular Angiotensin II formation blocks high glucose effect on mesangial matrix. Regulatory Peptides , 2009, 158(1-3): 103-109.

3 陈建明, 张国伟, 李耀平, 邱 明, 应奇才.单细胞凝胶电泳技术检测甲醛对人肝癌细胞 HepG2的遗传毒性效应.杭州师范大学学报(自然科学版) , 2009, (3): 199-202.

4 Jianming Chen, Ravichandran Panchanathan, & Divaker Choubey. Stimulation of T cells up-regulates expression of Ifi202, an interferon-inducible lupus susceptibility gene, through activation of JNK/c-Jun pathway. Immunology Letters, 2008; 118(1):13-20.

5 Fatouma Alimirah, Jianming Chen, Francesca J. Davis, and Divaker Choubey. IFI16 in Human Prostate Cancer. Molecular Cancer Research, 2007; 5(3): 251-259.

6 Fatouma Alimirah, Ravichandran Panchanathan, Jianming Chen, Xiang Zhang, Shuk-mei Ho and Divaker Choubey. Expression of androgen receptor is negatively regulated by p53. Neoplasia, 2007; 9(12):1152-1159.

7 Fatouma Alimirah, Ravichandran Panchanathan, Francesca Davis, Jianming Chen, and Divaker Choubey. Restoration of p53 expression in human cancer cell lines upregulates the expression of Notch1: implications for cancer cell fate determination after genotoxic stress. Neoplasia, 2007; 9(5): 427-434.

8 Ying Zhang, Jianming Chen, Channabasavaiah B. Gurumurthy, JunHyun Kim, Ishfaq Bhat, Qingshen Gao, Goberdhan Dimri, Sam W. Lee, Hamid Band and Vimla Band. The human orthologue of Drosophila ecdysoneless protein interacts with p53 and regulates its function. Cancer Research, 2006; 66(14): 7167-7175.

9 Fatouma Alimirah, Jianming Chen, Hong Xin, and Divaker Choubey. Androgen receptor auto-regulates its expression by a negative feedback loop through up-regulation of IFI16 protein. FEBS Letters, 2006; 580(6):1659-1664.

10 Fatouma Alimirah, Jianming Chen, Zane Basrawala, Hong Xin, and Divaker Choubey. DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation. FEBS Letters, 2006; 580(9): 2294-2300.

11 Qi-En Wang, Manzoor A. Wani, Jianming Chen, Qianzheng Zhu, Gulzar Wani, Mohamed El-Mahdy, and Altaf. A. Wani. Cellular Ubiquitination and Proteasomal Functions Positively Modulate Mammalian Nucleotide Excision Repair. Molecular Carcinogenesis, 2005; 42 (1): 53-64.

12 Qianzheng Zhu, Jihong Yao, Gulzar Wani, Jianming Chen, Qi-En Wang, and Altaf A. Wani. The ubiquitin-proteasome pathway is required for the function of the viral VP16 transcriptional activation domain. FEBS Letters, 2004; 556(1-3): 19-25.

13 Qi-En Wang, Qianzheng Zhu, Gulzar Wani, Jianming Chen, and Altaf A Wani. UV Radiation-Induced XPC Translocation within Chromatin is Mediated by DNA Damage-Binding Protein, DDB2. Carcinogenesis, 2004; 25(6):1033-1043.

14 Qi-en Wang, Qianzheng Zhu, Manzoor A.Wani, Gulzar Wani, Jianming Chen, and Altaf Wani. Tumor suppressor p53 dependent recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage. DNA Repair, 2003; 2: 483-499.