一、个人简历

吴晓梅，女，1982年生，浙江义乌人，博士，讲师。

2000.9-2004.7：北京师范大学，信息与科学技术学院，理学学士

2004.9-2009.7：北京师范大学，生命科学学院，理学博士

2009.8-2011.11：美国佐治亚大学，植物系，博士后

2011.12-至今： 杭州师范大学，生命与环境科学学院，讲师

二、主授课程

1.《基因组学概论》，生科院专升本

2.《生物信息学》，生科院专升本

三、教研项目（教学先，科研后）

1. 蛋白质 - 蛋白质相互作用网络的时空动态分解研究——以酵母基因组为例 (31200625)，国家自然科学基金青年基金，2013.1-2015.12，主持20万

2. 基于Gene Ontology的语义相似性算法的开发及其在功能基因组中的应用研究，教育部留学回国人员科研启动基金（第47批），2014.1-2014.12，主持3万

四、主要成果

l 科研论文

1.Wu, X.*, Wu, F.H., Wang, X., Wang, L., Siedow, J.N., Zhang, W. and Pei, Z.M.* (2014) Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING. Nucleic Acids Research, 42(13):8243-8257 [被引频次6].

2. Wu, X.*, Pang, E., Lin, K. and Pei, Z.M. (2013) Improving the measurement of semantic similarity between Gene Ontology terms and gene products: insights from an edge- and IC-based hybrid method. PLoS One 8(5), e66745 [被引频次12].

3.Bennetzen, J.L.*, Schmutz, J., Wang, H., Percifield, R., Hawkins, J., Pontaroli, A.C., Estep, M., Feng, L., Vaughn, J.N., Grimwood, J., Jenkins, J., Barry, K., Lindquist, E., Hellsten, U., Deshpande, S., Wang, X., Wu, X., Mitros, T., Triplett, J., Yang, X., Ye, C.Y., Mauro-Herrera, M., Wang, L., Li, P., Sharma, M., Sharma, R., Ronald, P.C., Panaud, O., Kellogg, E.A., Brutnell, T.P., Doust, A.N., Tuskan, G.A., Rokhsar, D., and Devos, K.M. (2012) Reference genome sequence of the model plant setaria. Nature Biotechnology 30(6): 555-561 [被引频次137].

4. Wu, X., Guo, J., Zhang, D.Y. and Lin, K.* (2009) The properties of hub proteins in a yeast-aggregated cell cycle network and its phase sub-networks. Proteomics 9:4812-4824 [被引频次7].

5. Guo, J., Wu, X., Zhang, D.Y. and Lin, K.* (2008) Genome-wide inference of protein interaction sites: lessons from the yeast high-quality negative protein–protein interaction dataset. Nucleic Acids Research 36(6): 2002-2011.

6. Wu, X., Zhu, L., Guo, J., Fu, C., Zhou, H.J, Dong, D., Li, Z.B, Zhang, D.Y. and Lin, K.* (2006) SPIDer: Saccharomyces protein-protein interaction database. BMC Bioinformatics 7, S16 [被引频次15].

7. Wu, X., Zhu, L, Guo, J, Zhang, D.Y and Lin, K.* (2006). Prediction of yeast protein–protein interaction network: insights from the Gene Ontology and annotations. Nucleic Acids Research 34(7): 2137-2150 [被引频次104].

l 获奖情况

2010：北京市优秀博士学位论文