赵晓枫，博士，副教授，硕士研究生导师，杭州市131人才，杭州市高层次人才。一直从事中枢神经系统胶质细胞发育及其相关疾病分子机制研究，近年着重研究衰老相关胶质细胞的变化和功能以及相关药物评估和作用机制。研究结果不仅有助于理解胶质细胞发育涉及的分子调控网络，更为临床中衰老相关的神经退行性疾病的治疗提供相关的理论基础和分子手段。

在本领域高水平期刊发表科研论文28篇，并作为SCI杂志Scientific Reports、Neuroscience Bulletin的审稿专家，国家自然科学基金项目评审专家，浙江省自然科学基金评审专家，广东省自然科学基金省外评审专家。主持国家自然科学基金项目4项、浙江省自然科学基金一般项目1项、杭州留学回国人员创新类项目1项，作为学术骨干参与科技部科技创新2030-“脑科学与类脑研究”重大专项。

联系方式：zxf79@sina.com，0571-28860500

研究工作经历

2015-今，杭州师范大学，生命与环境科学学院生物系，副教授，硕士生导师

2015/12-2016/12，美国Emory大学，医学院药学系，访问学者

2010/09-2012/05，美国路易斯维尔大学，解剖科学与神经生物学系，博士后

2007/07-2009/09，浙江大学，生物学博士后流动站，博士后

2002/09-2007/06，浙江大学，动物科学学院动物科学系，博士

主持项目

1. 国家自然科学基金面上项目少突胶质细胞对海马脑区苔藓纤维出芽的影响及其对癫痫发生的作用研究（项目编号32471022，50万，2025.01.01-2028.12.31）

2.  国家自然科学基金面上项目少突胶质细胞分化和髓鞘化过程中QKI转录上调及其同工蛋白QKI-6产生的分子机制和作用研究（项目编号32070965，58万，2021.01.01-2024.12.31）

3.    国家基金面上项目中枢神经系统髓鞘形成过程中基于Nkx2.2的转录及转录后调控研究（项目编号 31471955，89万，2015.01.01-2018.12.31）

4.    国家基金青年基金项目Nkx2.2对髓鞘基因表达的转录调控及其在髓鞘结构维持中的作用 (项目编号：31000488，20万，2010.01.01-2013.12.31)

5.    浙江省自然科学基金一般项目TAPP1 在少突胶质细胞分化及髓鞘化过程中的作用研究（项目编号：Y17C090017, 10万，2017.01.01-2019.12.31）

6.    杭州市科委农业自主项目抑制素基因免疫提高地方鸡种繁殖性能研究 （项目编号：20160432B01，20万，2016.01.01-2018.12.31）

7.    杭州市留学归国人员创新性项目 RNA结合蛋白QKI 促进髓鞘产生的分子机制及其相关药物应用研究 （10万 2018）

发表文章

1. Liu X, Li C, Li J, Xie L, Hong Z, Zheng K, Zhao X, Yang A, Xu X, Tao H, Qiu M, Yang J. EGF signaling promotes the lineage conversion of astrocytes into oligodendrocytes. Mol Med. 2022 May 4;28(1):50.

2. Yu D, Wu Y, Zhu L, Wang Y, Sheng D, Zhao X, Liang G, Gan L. The landscape of the long non-coding RNAs in developing mouse retinas. BMC Genomics. 2023 May 10;24(1):252. doi: 10.1186/s12864-023-09354-w.

3. Mei R, Qiu W, Yang Y, Xu S, Rao Y, Li Q, Luo Y, Huang H, Yang A, Tao H, Qiu M, Zhao X. Evidence That DDR1 Promotes Oligodendrocyte Differentiation during Development and Myelin Repair after Injury. Int J Mol Sci. 2023 Jun 19;24(12):10318.

4. Jiang C, Qiu W, Yang Y, Huang H, Dai ZM, Yang A, Tang T, Zhao X, Qiu M. ADAMTS4 Enhances Oligodendrocyte Differentiation and Remyelination by Cleaving NG2 Proteoglycan and Attenuating PDGFRα Signaling. J Neurosci. 2023 Jun 14;43(24):4405-4417. doi: 10.1523/JNEUROSCI.2146-22.2023. Epub 2023 May 15.

5. Fu JY, Jiang CX, Wu MY, Mei RY, Yang AF, Tao HP, Chen XJ, Zhang J, Huang L, Zhao XF. Theabrownin Induces Cell Apoptosis and Cell Cycle Arrest of Oligodendroglioma and Astrocytoma in Different Pathways. Front Pharmacol. 2021 Apr 30;12:664003.

6. Wu XQ, Fu JY, Mei RY, Dai XJ, Li JH, Zhao XF, Liu MQ. Inhibition of Liver Cancer HepG2 Cell Proliferation by Enzymatically Prepared Low-molecular Citrus Pectin. Curr Pharm Biotechnol. 2022;23(6):861-872.

7. Wang M, Zhang E, Yu C, Liu D, Zhao S, Xu M, Zhao X, Yue W, Nie G. Enzyme Changing the Structure and Behaviors of Chitosan/γ-poly(glutamic acid) Hydrogel for Potential Skin Care. Polymers (Basel). 2022 May 19;14(10):2070.

8. Ju J, Yang X, Jiang J, Wang D, Zhang Y, Zhao X, Fang X, Liao H, Zheng L, Li S, Hou ST, Liang L, Pan Y, Li H, Li N. Structural and Lipidomic Alterations of Striatal Myelin in 16p11.2 Deletion Mouse Model of Autism Spectrum Disorder. Front Cell Neurosci. 2021 Aug 12;15:718720.

9. Mei R, Fu J, Jiang C, Yang J, Zheng K, Yang A, Qiu M, Zhao X. TAPP1 Represses the Differentiation of Oligodendrocyte and its Deficiency Accelerates Myelin Regeneration after Demyelinating Injuries. Neurosci Bull. 2021 Mar;37(3):385-388.

10. Liu X, Zhao X, Qiu M, Yang J. Cell surface receptor-mediated signaling in CNS regeneration. Neuroscience. 2024 Oct 30:S0306-4522(24)00566-9.

11. Mei R, Huang L, Wu M, Jiang C, Yang A, Tao H, Zheng K, Yang J, Shen W, Chen X, Zhao X, Qiu M. Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II +Type I/II Oligodendrocytes and the Sizes of Myelin Fibers. Front Cell Neurosci. 2021 Sep 22;15:751439.

12. Xinyu Liu, Conghui Li, Kang Zheng, Xiaofeng Zhao, Xiaofeng Xu, Aifen Yang, Min Yi, Huaping Tao, Binghua Xie, Mengsheng Qiu & Junlin Yang. Chromosomal aberration arises during somatic reprogramming to pluripotent stem cells. Cell Div. 2020 Nov 3;15(1):12.

13. Xu YP, Wang LZ, Zhou YL, Xiao Y, Gu WB, Li B, Zhao XF, Dong WR, Shu MA. Identification and functional analysis of two interferon regulatory factor 3 genes and their involvement in antiviral immune responses in the Chinese giant salamander Andrias davidianus. Dev Comp Immunol. 2020 Sep;110:103710. 14.    Wang LZ, Xu YP, Zhou YL, Liu ZP, Li B, Gu WB, Zhao XF, Dong WR, Shu MA. The first evidence of four transcripts from two Interleukin 18 genes in animal and their involvement in immune responses in the largest amphibian Andrias davidianus. Dev Comp Immunol. 2020 May;106:103598.

15. Chen X, Wang F, Gan J, Zhang Z, Liang X, Li T, Huang N, Zhao X, Mei F, Xiao L. Myelin Deficits Caused by Olig2 Deficiency Lead to Cognitive Dysfunction and Increase Vulnerability to Social Withdrawal in Adult Mice. Neurosci Bull. 2020 Apr;36(4):419-426.

16. Wan Y, Liu X, Zheng D, Wang Y, Chen H, Zhao X, Liang G, Yu D, Gan L. Systematic identification of intergenic long-noncoding RNAs in mouse retinas using full-length isoform sequencing. BMC Genomics. 2019 Jul 8;20(1):559. 17.    Zheng K, Wang C, Yang J, Huang H, Zhao X, Zhang Z, Qiu M. Molecular and Genetic Evidence for the PDGFRα-Independent Population of Oligodendrocyte Progenitor Cells in the Developing Mouse Brain. J Neurosci. 2018 Oct 31;38(44):9505-9513.

18. Jiang C, Yang W, Fan Z, Teng P, Mei R, Yang J, Yang A, Qiu M, Zhao X. AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination. Neurosci Bull. 2018 Jun;34(3):527-533.

19.  Chen X, Ku L, Mei R, Liu G, Xu C, Wen Z, Zhao X, Wang F, Xiao L, Feng Y. Novel schizophrenia risk factor pathways regulate FEZ1 to advance oligodendroglia development. Transl Psychiatry. 2017 Dec 18;7(12):1293. 20. Huang H, Teng P, Mei R, Yang A, Zhang Z, Zhao X, Qiu M. Tmeff2 is expressed in differentiating oligodendrocytes but dispensable for their differentiation in vivo. Sci Rep. 2017 Mar 23;7(1):337.

21. Cheng X, Xie B, Qi J, Zhao X, Zhang Z, Qiu M, Yang J. Rat astrocytes are more supportive for mouse OPC self-renewal than mouse astrocytes in culture. Dev Neurobiol. 2017 Sep;77(8):907-916.

22. Yang J, Cheng X, Shen J, Xie B, Zhao X, Zhang Z, Cao Q, Shen Y, Qiu M. A Novel Approach for Amplification and Purification of Mouse Oligodendrocyte Progenitor Cells. Front Cell Neurosci. 2016 Aug 22;10:203.

23. Zhu Q, Tan Z, Zhao S, Huang H, Zhao X, Hu X, Zhang Y, Shields CB, Uetani N, Qiu M. Developmental expression and function analysis of protein tyrosine phosphatase receptor type D in oligodendrocyte myelination. Neuroscience. 2015 Nov 12;308:106-14.

24. Chen Y, Mei R, Teng P, Yang A, Hu X, Zhang Z, Qiu M, Zhao X. TAPP1 inhibits the differentiation of oligodendrocyte precursor cells via suppressing the Mek/Erk pathway. Neurosci Bull. 2015 Oct;31(5):517-26.

25. Zhao X, Chen Y, Zhu Q, Huang H, Teng P, Zheng K, Hu X, Xie B, Zhang Z, Sander M, Qiu M. Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor. PLoS One. 2014 Oct 6;9(10):e109171.

26. Zhao X, Huang H, Chen Y, Liu Y, Zhang Z, Ma Q, Qiu M. Dynamic expression of secreted Frizzled-related protein 3 (sFRP3) in the developing mouse spinal cord and dorsal root ganglia. Neuroscience. 2013 Sep 17;248:594-601.

27. Huang H, Zhao XF, Zheng K, Qiu M. Regulation of the timing of oligodendrocyte differentiation: mechanisms and perspectives. Neurosci Bull. 2013 Apr;29(2):155-64.

28.   Zhu Q, Whittemore SR, Devries WH, Zhao X, Kuypers NJ, Qiu M*. Dorsally-derived oligodendrocytes in the spinal cord contribute to axonal myelination during development and remyelination following focal demyelination. Glia, 59(11), 1612-1621. 2011.

                                        （于2024年11月5日更新）