讲课时间：2018年11月2日（星期五）13:20-15:50

讲课题目：癌症的分子生物学

主讲人：美国路易斯维尔大学丁继翔教授

地点：下沙校区教学楼C-102室

主讲人简介：

丁继翔教授，男，博士生导师，1989年毕业于杭州大学生物系（现浙江大学生命科学学院），获生化与微生物专业学士学位；1995年毕业于英国曼彻斯特大学，获发育生物学专业博士学位；1995.12–2001.06，在美国Rutgers 大学医学院从事博士后研究工作；2001.07–2002.11，担任美国Rutgers 大学医学院讲师（Instructor）；2002.12– 2007.06，担任美国路易斯威尔大学助理教授（tenure track Assistant Professor）；2007.07–至今，担任美国路易斯威尔大学副教授(tenured Associate Professor)。

丁继翔教授主要研究胚胎发育与先天性疾病的机理，包括： 胚胎早期发育中原肠运动过程，中轴线的形成以及先天性前脑无分离畸形（Holoprosencephaly 或 Cyclops ) 的发生机理；面额发育及腭裂（Cleft Palate)的机制；心血管系统发育及先天性心脏病的发生；干细胞生物学及组织再生和修复。他在Nature、Science、Development等杂志上发表多篇高水平论文，是该领域的知名专家。

欢迎广大师生积极踊跃参加！

代表性论文：

1. Proetzel, G., Pawlowski, S., Wiles, M., Yin, M., Boivin, G., Howles, P., Ding, J., Ferguson, M., and Doetschman, T*. (1995) Transforming growth factor- 3 is required for secondary palate fusion. Nature Genetics.11, 409-414.

2. Ding, J., Yang, L., Yan, Y.-T., Chen, A., Desai, N., Wynshaw-Boris, A. and Shen, M. M *. (1998). Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo. Nature. 395, 702-707 (with News & Views).

3. Mudgett, J. S.^#, Ding, J.^#, Guh-Siesel, L., Chartrain, N. A., Yang, L., and Shen, M. M*. (2000). Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis.. Proc. Natl. Acad. Sci. USA. 97, 10454-10459. (^# co-first author).

4.  Iratni, R., Yan, Y.-T., Chen, C., Ding, J., Zhang, Y., Price, S. M., Reinberg, D., and Shen, M. M. (2002). Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1. Science. 298, 1996-1999.

5. Jin, J – Z. and Ding, J*. (2006) Analysis of cell migration, trans-differentiation and apoptosis during mouse secondary palate fusion. Development. 133, 3341-3347.

6.Jin JZ, Tan M, Warner DR, Darling DS, Higashi Y, Gridley T and Ding J*. (2010) Mesenchymal cell remodeling during mouse secondary palate reorientation. Dev Dyn. 239, 2110-7.

7.Jin JZ and Ding J*. (2013) Cripto is required for mesoderm and endoderm cell allocation during mouse gastrulation. Dev Biol. 381, 170-8.

8.Jin JZ, Tan M and Ding J*. (2013) Analysis of Cripto expression during mouse cardiac myocyte differentiation. Int J Dev Biol. 57, 793-7.

9. Jin JZ, Warner DR, Lu Q, Pisano MM, Greene RM, Ding J* (2014) Deciphering TGF-β3 function in medial edge epithelium specification and fusion during mouse secondary palate development. Dev Dyn. 243,1536-43.

10.Jin JZ and Ding J*. (2014) Strain-dependent effects of transforming growth factor-β1 and 2 during mouse secondary palate development. Reprod Toxicol. 50,129-33.

11.Jin JZ, Warner DR and Ding J*. (2014) Regional specification of palate medial edge epithelium along the anterior to posterior axis. Int J Dev Biol. 58, 713-717.

12.Jin JZ and Ding J*. (2015) Strain-Dependent Gene Expression during Mouse Embryonic Palate Development. J Dev Biol. 3, 2-10.

13.Jin J, Zhu Y, Warner D, Ding J*. (2016) Analysis of extraembryonic mesodermal structure formation in the absence of morphological primitive streak. Dev Growth Differ. 58, 522-9.

14.Jin JZ, Lei Z, Lan ZJ, Mukhopadhyay P and Ding J*. (2018) Inactivation of Fgfr2 gene in mouse secondary palate mesenchymal cells leads to cleft palate. Reprod Toxicol. 77:137-142.