姓名: 孙佳慧，女，博士，副研究员，硕士生导师

办公电话：0571-28867021

邮箱：sunjh@hznu.edu.cn

课题组网站：

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【研究领域】

癫痫相关的谷氨酸受体结构及发病机制。谷氨酸受体/辅助亚基的结构、生理功能及调控机制。突触传递、突触可塑性和髓鞘可塑性。

【主讲课程】

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【教育和工作经历】

2022/1-现在，杭州师范大学，生命与环境科学学院，教师

2016/9-2021/6，南京大学，博士

2012/9-2016/6，东北农业大学，学士

【学术简介（限200字）】

主要致力于神经疾病分子机制的研究，以分子生物学、生物化学等研究手段结合离体和在体电生理等实验技术，在兴奋性神经递质谷氨酸受体与其辅助蛋白在癫痫等疾病发病机制中的作用上作出创新性发现。迄今为止共参与发表9篇sci论文，分别发表于Nature、Molecular Psychiatry、Plos Genetics、Journal of Biological Chemistry等著名国际期刊上面。

【主持教学科研项目】省部级以上

1.国家自然科学基金青年项目，突触蛋白Densin在少突胶质细胞中调控髓鞘可塑性的作用和机制研究（2023/1-2025/12）。

【代表性论著】

1. Sun, J.H., Chen, J., Ayala Valenzuela, F.E., Brown, C., Masser-Frye, D., Jones, M., Romero, L.P., Rinaldi, B., Li, W.L., Li, Q.Q., et al. (2021). X-linked neonatal-onset epileptic encephalopathy associated with a gain-of-function variant p.R660T in GRIA3. PLoS Genet 17, e1009608.

2. He, L., Sun, J., Gao, Y., Li, B., Wang, Y., Dong, Y., An, W., Li, H., Yang, B., Ge, Y., et al. (2021). Kainate receptor modulation by NETO2. Nature 599, 325-329.

3. Li, Y.J., Duan, G.F., Sun, J.H., Wu, D., Ye, C., Zang, Y.Y., Chen, G.Q., Shi, Y.Y., Wang, J., Zhang, W., et al. (2019). Neto proteins regulate gating of the kainate-type glutamate receptor GluK2 through two binding sites. J Biol Chem 294, 17889-17902.

4. Hamanaka, K., Miyoshi, K., Sun, J.H., Hamada, K., Komatsubara, T., Saida, K., Tsuchida, N., Uchiyama, Y., Fujita, A., Mizuguchi, T., et al. (2022). Amelioration of a neurodevelopmental disorder by carbamazepine in a case having a gain-of-function GRIA3 variant. Hum Genet 141, 283-293.

5. Li, Q.Q., Chen, J., Hu, P., Jia, M., Sun, J.H., Feng, H.Y., Qiao, F.C., Zang, Y.Y., Shi, Y.Y., Chen, G., et al. (2022). Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory. Mol Psychiatry 27, 3468-3478.

6. Hu, P., Wu, D., Zang, Y.Y., Wang, Y., Zhou, Y.P., Qiao, F., Teng, X.Y., Chen, J., Li, Q.Q., Sun, J.H., et al. (2022). A novel LGI1 mutation causing autosomal dominant lateral temporal lobe epilepsy confirmed by a precise knock-in mouse model. CNS Neurosci Ther 28, 237-246.

7. Peng, S.X., Pei, J., Rinaldi, B., Chen, J., Ge, Y.H., Jia, M., Wang, J., Delahaye-Duriez, A., Sun, J.H., Zang, Y.Y., et al. (2022). Dysfunction of AMPA receptor GluA3 is associated with aggressive behavior in human. Mol Psychiatry 27, 4092-4102.

8. Yu, Y., Yang, Z., Jin, B., Qin, X., Zhu, X., Sun, J., Huo, L., Wang, R., Shi, Y., Jia, Z., et al. (2020). Cannabidiol inhibits febrile seizure by modulating AMPA receptor kinetics through its interaction with the N-terminal domain of GluA1/GluA2. Pharmacol Res 161, 105128.

9. Rinaldi, B., Ge, Y.H., Freri, E., Tucci, A., Granata, T., Estienne, M., Sun, J.H., Gérard, B., Bayat, A., Efthymiou, S., et al. (2022). Myoclonic status epilepticus and cerebellar hypoplasia associated with a novel variant in the GRIA3 gene. Neurogenetics 23, 27-35.

【荣誉与奖励】省部级以上

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【授权专利及转化】

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