雷明光，教授，博导

办公电话：18918968091

邮箱：mglei@hznu.edu.cn

【研究领域】

研究植物磷信号感受机制、信号转导和调控网络，以及植物低磷响应的表观遗传学机制，挖掘优异基因资源，培育磷高效吸收和利用的农作物；开发基因编辑新技术和新方法，创制农作物新种质，提高农作物的产量和品质、抗逆性和资源利用效率。

【主讲课程】

生物化学、生命科学导论、基因编辑与种质创新

【教育和工作经历】

教育经历：

1996.09–2000.07  北京林业大学，学士

2000.09–2003.07  清华大学，硕士

2006.09–2011.07  清华大学，博士

工作经历：

2011.10–2015.07  美国普渡大学，博士后

2015.08–2020.04  中国科学院上海生命科学研究院，研究员，课题组长

2020.05–2024.01  中国科学院分子植物科学卓越创新中心，研究员，课题组长

2024.02–至今  杭州师范大学生命与环境科学学院，教授

【学术简介】

发现植物细胞内磷信号分子InsP8并解析其感受机制（Mol Plant, 2019; Nat Commun, 2021）；揭示转录因子SHR稳定PHO1、调控磷在根-地上部间分配的机制（Nat Plants, 2022）；发现番茄顺式天然反义转录调控多聚腺苷酸化响应磷饥饿的新机制（Nat Commun, 2025）；鉴定去泛素化酶UCH2去除H2A.Z泛素化修饰、激活磷饥饿响应基因（Nat Commun, 2026）。

【主持教学科研项目】

1. 国家海外引才计划青年项目，200万元，2016.01–2018.12，负责人

2. UCH2去泛素化H2A.Z调控植物低磷胁迫响应的研究，国家自然科学基金委面上项目，2026.01–2029.12，50万元，负责人

3. GhRAPS2和GhRAPS1调控棉花低磷信号感知和根际酸化反应的分子机制，国家自然科学基金联合基金重点支持项目，2025.01–2028.12，260万元，主要参与人

4. 一个组蛋白识别器DUF6调控拟南芥DNA主动去甲基化的分子机理，国家自然科学基金委面上项目，60万元，2020.01–2023.12，负责人

5. 染色质重塑因子BRM调控低磷条件下根系重塑的分子机理，上海市科委项目，20万元，2022.04–2025.03，负责人

6. SnRK2调控植物低磷响应的研究，上海市科委项目，30万元，2018.10–2022.10，负责人

【代表性论著】（^#共同一作，*通讯作者）

1. Meng F^#, Xiao X^#, Ma G^#, Satheesh V, Wu Q, Zhao Y, Chen H, Lu X, Jiang J, Lei M^*. A ubiquitin carboxyl-terminal hydrolase facilitates H2A.Z removal in response to phosphate starvation. Nat Commun. 2026, doi:10.1038/s41467-026-77882-6

2. Tan S^#, Xiang Y^#, Soltani A, Lei M^*. Molecular basis of quinoa's resilience to abiotic stresses: implications for climate-adaptive crop breeding. Front Plant Sci. 2026 Jul 8;17:1865530.

3. Lv Q, Soltani A, Lei M^*, Ma G^*. Autophagy in plants: molecular mechanisms and roles in abiotic stress responses. Front Plant Sci. 2026 Jun 18;17:1861141.

4. Dong J^#, Zhang K^#, Song M, Xiao M, Lu X, Ge S, Zheng Z, Li M, Zhu JK, Lei M^*. CRISPR-mediated intronic knock-in of pre-amiRNA enables targeted gene silencing. Plant Commun. 2026 Sep 14;7(9):101916.

5. Ge S, Yuan K, Lei M^*. The SPX protein family in plants: from phosphate sensors to multifunctional signaling hubs. Stress Biol. 2026 May 8;6(1):36.

6. Ge S, Chen K, Guo F, Xiao M, Lv Q, An GY, Dong J, Lei M^*. Decoupling low phytic acid from growth penalties by targeting PHR1/PHL1 in Arabidopsis. Plant Biol. 2026 Jun 15.

7. Ge S^#, Li J^#, Ma H^#, Sánchez-Bermúdez M, Wu S, Lv Q, Guo F, Dong J, Ma G, Li QQ^*, Satheesh V^*, Lei M^*. A cis-natural antisense RNA regulates alternative polyadenylation of SlSPX5 under Pi starvation in tomato. Nat Commun. 2025, 16:7981.

8. Ge S^#, Xiao X^#, Zhang K, Yang C, Dong J, Chen K, Lv Q, Satheesh V, Lei M^*. A plastidial lipoyl synthase LIP1p plays a crucial role in phosphate homeostasis in Arabidopsis. Plant J. 2024, 120(6):2385-2397.

9. Dong C^#, Xi Y^#, Satheesh V, Lei M^*. Advances in CRISPR/Cas technologies and their application in plants. Tropical Plants. 2023, 2:2.

10. Satheesh V, Wahab A, Ramakrishnan M, Lei M^*. Molecular Mechanisms Underlying Phosphate Sensing and Signalling in Plants. In: Rouached H, Satbhai SB (eds) Plant Phosphorus Nutrition (1st ed.). CRC Press. 2023, 18-29.

11. Zhou X^#, Wei M^#, Nie W, Xi Y, Li P, Zheng Q, Tang K, Satheesh V, Wang Y, Luo J, Du X, Liu R, Yang Z, La H, Zhong Y, Yang Y, Zhu JK, Du J, Lei M*. The H3K9me2-binding protein AGDP3 limits DNA methylation and transcriptional gene silencing in Arabidopsis. J Integr Plant Biol. 2022, 64(12):2385-2395.

12. Xiao X^#, Zhang J^#, Satheesh V, Meng F, Gao W, Dong J, Zheng Z, An GY, Nussaume L, Liu D, Lei M*. SHORT-ROOT stabilizes PHOSPHATE1 to regulate phosphate allocation in Arabidopsis. Nat Plants. 2022, 8:1074-1081.

13. Ma G, Satheesh V, Lei M*. Intracellular phosphate sensing in plants. Mol Plant. 2022 Dec 5;15(12):1831-1833.

14. Li T^#, Zhang R^#, Satheesh V, Wang P, Ma G, Guo J, An GY, Lei M*. The Chromatin Remodeler BRAHMA Recruits HISTONE DEACETYLASE6 to Regulate Root Growth Inhibition in Response to Phosphate Starvation in Arabidopsis. J Integr Plant Biol. 2022, 64(12):2314-2326

15. Xiao X, Meng F, Satheesh V, Xi Y, Lei M*. An Agrobacterium-mediated transient expression method contributes to functional analysis of a transcription factor and potential application of gene editing in Chenopodium quinoa. Plant Cell Rep. 2022, 41:1975-1985.

16. Satheesh V^#, Zhang J^#, Li J, You Q, Zhao P, Wang P, Lei M*. High transcriptome plasticity drives phosphate starvation responses in tomato. Stress Biol. 2022, 2:18.

17. Satheesh V, Tahir A, Li J, Lei M*. Plant phosphate nutrition: sensing the stress. Stress Biol. 2022, 2:16.

18. Zhou J^#, Hu Q^#, Xiao X, Yao D, Ge S, Ye J, Li H, Cai R, Liu R, Meng F, Wang C, Zhu JK, Lei M^*, Xing W^*. Mechanism of phosphate sensing and signaling revealed by rice SPX1-PHR2 complex structure. Nat Commun. 2021, 12:7040.

19. Satheesh V., Li J., Lei M^*. Efficient CRISPR-Cas9-Mediated Genome Editing in Tomato. In: Islam M.T., Molla K.A. (eds) CRISPR-Cas Methods. Springer Protocols Handbooks. Humana, New York, NY. 2021, 159-177.

20. Dong J^#, Ma G^#, Sui L^#, Wei M, Satheesh V, Zhang R, Ge S, Li J, Zhang TE, Wittwer C, Jessen HJ, Zhang H, An GY, Chao DY, Liu D, Lei M^*. Inositol Pyrophosphate InsP8 Acts as an Intracellular Phosphate Signal in Arabidopsis. Mol Plant. 2019, 12:1463-1473.

21. Nie WF^#, Lei M^#, Zhang M, Tang K, Huang H, Zhang C, Miki D, Liu P, Yang Y, Wang X, Zhang H, Lang Z, Liu N, Xu X, Yelagandula R, Zhang H, Wang Z, Chai X, Andreucci A, Yu JQ, Berger F, Lozano-Duran R, Zhu JK^*. Histone acetylation recruits the SWR1 complex to regulate active DNA demethylation in Arabidopsis. Proc Natl Acad Sci U S A. 2019, 116(33):16641-16650.

22. Satheesh V, Zhang H, Wang X, Lei M^*. Precise editing of plant genomes – Prospects and challenges. Semin Cell Dev Biol. 2019, 96:115-123

23. Xiao X, Zhang J, Li T, Fu X, Satheesh V, Niu Q, Lang Z, Zhu JK^*, Lei M^*. A group of SUVH methyl-DNA binding proteins regulate expression of the DNA demethylase ROS1 in Arabidopsis. J Integr Plant Biol. 2019, 61(2):110-119.

24. Zhao P^*, You Q, Lei M^*. A CRISPR/Cas9 deletion into the phosphate transporter SlPHO1;1 reveals its role in phosphate nutrition of tomato seedlings. Physiol Plant. 2019, 167(4):556-563.

25. Lei M, Zhang H, Julian R, Tang K, Xie S, Zhu JK^*. Regulatory link between DNA methylation and active demethylation in Arabidopsis. Proc Natl Acad Sci U S A. 2015,112(11):3553-7.

26. Lang Z^#, Lei M^#, Wang X, Tang K, Miki D, Zhang H, Mangrauthia SK, Liu W, Nie W, Ma G, Yan J, Duan CG, Hsu CC, Wang C, Tao WA, Gong Z, Zhu JK^*. The methyl-CpG-binding protein MBD7 facilitates active DNA demethylation to limit DNA hyper-methylation and transcriptional gene silencing. Mol Cell. 2015,57(6):971-983.

27. Qian W^#, Miki D^#, Lei M^#, Zhu X, Zhang H, Liu Y, Li Y, Lang Z, Wang J, Tang K, Liu R, Zhu JK^*. Regulation of active DNA demethylation by an α-crystallin domain protein in Arabidopsis. Mol Cell. 2014,55(3):361-71.

28. Lei M^#, La H^#, Lu K, Wang P, Miki D, Ren Z, Duan CG, Wang X, Tang K, Zeng L, Yang L, Zhang H, Nie W, Liu P, Zhou J, Liu R, Zhong Y, Liu D, Zhu JK^*. Arabidopsis EDM2 promotes IBM1 distal polyadenylation and regulates genome DNA methylation patterns. Proc Natl Acad Sci U S A. 2014,111(1):527-32.

29. Lei M, Liu D^*. Sucrose regulates plant responses to deficiencies in multiple nutrients. Plant Signal Behav. 2011,6(8):1247-9.

30. Lei M, Liu Y, Zhang B, Zhao Y, Wang X, Zhou Y, Raghothama KG, Liu D^*. Genetic and genomic evidence that sucrose is a global regulator of plant responses to phosphate starvation in Arabidopsis. Plant Physiol. 2011,156(3):1116-30.

31. Lei M, Zhu C, Liu Y, Karthikeyan AS, Bressan RA, Raghothama KG, Liu D^*. Ethylene signalling is involved in regulation of phosphate starvation-induced gene expression and production of acid phosphatases and anthocyanin in Arabidopsis. New Phytol. 2011,189(4):1084-95.