姓名: 雷明光

办公电话：18918968091

邮箱：mglei@hznu.edu.cn

【研究领域】

植物分子营养学：研究植物磷信号感受机制、信号转导和调控网络，以及植物低磷响应的表观遗传学机制，挖掘优异基因资源，培育磷高效吸收和利用的农作物。

农作物生物育种：开发基因编辑新技术和新方法，创制农作物新种质，提高农作物的产量和品质、抗逆性和资源利用效率。

【主讲课程】

【教育和工作经历】

教育经历：

1996.09-2000.07 北京林业大学，学士

2000.09-2003.07 清华大学，硕士

2006.09-2011.07 清华大学生命科学学院，博士

工作经历：

2003.08-2006.08 清华大学生物系，工程师

2011.10-2015.07 美国普渡大学园艺与风景园林系，博士后，导师 朱健康院士

2015.08-2020.04 中国科学院上海生命科学研究院，研究员，课题组长

2020.05-2024.01 中国科学院分子植物科学卓越创新中心，研究员，课题组长

2024.02-       杭州师范大学生命与环境科学学院，研究员

【学术简介（限200字）】

首先发现多磷酸肌醇InsP₈是植物细胞内的磷信号分子（Dong et al., Molecular Plant, 2019），并解析了磷信号分子的感受机制（Zhou et al., Nature Communications, 2021）。发现一个控制根系发育的转录因子SHR通过控制木质部磷装载关键因子PHO1的蛋白稳定性，调控磷在根冠间的分配（Xiao et al., Nature Plants, 2022）。

鉴定出一个组蛋白乙酰化复合体IDM，阐明其调控DNA去甲基化酶ROS1的分子机制（Qian et al., Molecular Cell, 2014; Lang et al., Molecular Cell, 2015）。发现SWR1复合体可以识别组蛋白H3乙酰化，沉积组蛋白变体H2A.Z直接募集ROS1（Nie et al., PNAS, 2019 ）。发现一个DNA甲基化感应器，能够感受DNA甲基化水平，调控DNA去甲基化活性（Lei et al., PNAS, 2015; Xiao et al., J Integr Plant Biol, 2019）。

【主持教学科研项目】省部级以上

1.一个组蛋白识别器DUF6调控拟南芥DNA主动去甲基化的分子机理，2020.01-2023.12，自然科学基金委面上项目，负责人

2.SnRK2调控植物低磷响应的研究，2018.10-2022.10，上海市科委项目，负责人

3.染色质重塑因子BRM调控低磷条件下根系重塑的分子机理，2022.04-2025.03，上海市科委项目，负责人

【代表性论著】

Dong C., Xi Y., Satheesh V., Lei M^*. Advances in CRISPR/Cas technologies and their application in plants. Tropical Plants 2023, 2:2

Satheesh V., Wahab A., Ramakrishnan M., Lei M^*. Molecular Mechanisms Underlying Phosphate Sensing and Signalling in Plants. In: Rouached, H., & B. Satbhai, S. (eds) Plant Phosphorus Nutrition (1st ed.). CRC Press. 2023, 18-29

Zhou X, Wei M, Nie W, Xi Y, Li P, Zheng Q, Tang K, Satheesh V, Wang Y, Luo J, Du X, Liu R, Yang Z, La H, Zhong Y, Yang Y, Zhu JK, Du J, Lei M*. The H3K9me2-binding protein AGDP3 limits DNA methylation and transcriptional gene silencing in Arabidopsis. J Integr Plant Biol. 2022, 64(12):2385-2395.

Xiao X, Zhang J, Satheesh V, Meng F, Gao W, Dong J, Zheng Z, An GY, Nussaume L, Liu D, Lei M*. SHORT-ROOT stabilizes PHOSPHATE1 to regulate phosphate allocation in Arabidopsis. Nat Plants. 2022, 8:1074–1081

Ma G, Satheesh V, Lei M*. Intracellular phosphate sensing in plants. Mol Plant. 2022 Dec 5;15(12):1831-1833.

Li T, Zhang R, Satheesh V, Wang P, Ma G, Guo J, An GY, Lei M*. The Chromatin Remodeler BRAHMA Recruits HISTONE DEACETYLASE6 to Regulate Root Growth Inhibition in Response to Phosphate Starvation in Arabidopsis. J Integr Plant Biol. 2022, 64(12):2314-2326

Xiao X, Meng F, Satheesh V, Xi Y, Lei M*. An Agrobacterium-mediated transient expression method contributes to functional analysis of a transcription factor and potential application of gene editing in Chenopodium quinoa. Plant Cell Rep. 2022, 41:1975-1985.

Satheesh V^#, Zhang J^#, Li J, You Q, Zhao P, Wang P, Lei M*. High transcriptome plasticity drives phosphate starvation responses in tomato. Stress Biology, 2022, 2:18.

Satheesh V^#, Tahir A, Li J, Lei M*. Plant phosphate nutrition: sensing the stress. Stress Biology, 2022, 2:16。

Zhou J^#, Hu Q^#, Xiao X, Yao D, Ge S, Ye J, Li H, Cai R, Liu R, Meng F, Wang C, Zhu JK, Lei M^*, Xing W^*. Mechanism of phosphate sensing and signaling revealed by rice SPX1-PHR2 complex structure. Nat Commun, 2021, 12:7040

Satheesh V., Li J., Lei M^*. Efficient CRISPR-Cas9-Mediated Genome Editing in Tomato. In: Islam M.T., Molla K.A. (eds) CRISPR-Cas Methods. Springer Protocols Handbooks. Humana, New York, NY. 2021, 159-177

Satheesh V., Wahab A., Ramakrishnan M., Lei M^*. Molecular Mechanisms Underlying Phosphate Sensing and Signalling in Plants. In: Rouached, H., & B. Satbhai, S. (eds) Plant Phosphorus Nutrition (1st ed.). CRC Press. 2023, 18-29

Dong J^#, Ma G^#, Sui L^#, Wei M, Satheesh V, Zhang R, Ge S, Li J, Zhang TE, Wittwer C, Jessen HJ, Zhang H, An GY, Chao DY, Liu D, Lei M^*. Inositol Pyrophosphate InsP8 Acts as an Intracellular Phosphate Signal in Arabidopsis. Mol Plant. 2019, 12:1463-1473

Nie WF^#, Lei M^#, Zhang M, Tang K, Huang H, Zhang C, Miki D, Liu P, Yang Y, Wang X, Zhang H, Lang Z, Liu N, Xu X, Yelagandula R, Zhang H, Wang Z, Chai X, Andreucci A, Yu JQ, Berger F, Lozano-Duran R, Zhu JK^*. Histone acetylation recruits the SWR1 complex to regulate active DNA demethylation in Arabidopsis. Proc Natl Acad Sci U S A. 2019, 116(33):16641-16650.

Satheesh V^#, Zhang H, Wang X, Lei M^*. Precise editing of plant genomes – Prospects and challenges. Semin Cell Dev Biol. 2019, 96:115-123

Xiao X^#, Zhang J, Li T, Fu X, Satheesh V, Niu Q, Lang Z, Zhu JK^*, Lei M^*. A group of SUVH methyl-DNA binding proteins regulate expression of the DNA demethylase ROS1 in Arabidopsis. J Integr Plant Biol. 2019,61(2):110-119.

Zhao P^*, You Q, Lei M^*. A CRISPR/Cas9 deletion into the phosphate transporter SlPHO1;1 reveals its role in phosphate nutrition of tomato seedlings. Physiol Plant. 2019, 167(4):556-563.

Lei M^#, Zhang H, Julian R, Tang K, Xie S, Zhu JK^*. Regulatory link between DNA methylation and active demethylation in Arabidopsis. Proc Natl Acad Sci U S A. 2015,112(11):3553-7.

Lang Z^#, Lei M^#, Wang X, Tang K, Miki D, Zhang H, Mangrauthia SK, Liu W, Nie W, Ma G, Yan J, Duan CG, Hsu CC, Wang C, Tao WA, Gong Z, Zhu JK^*. The methyl-CpG-binding protein MBD7 facilitates active DNA demethylation to limit DNA hyper-methylation and transcriptional gene silencing. Mol Cell. 2015,57(6):971-983.

Qian W^#, Miki D^#, Lei M^#, Zhu X, Zhang H, Liu Y, Li Y, Lang Z, Wang J, Tang K, Liu R, Zhu JK^*. Regulation of active DNA demethylation by an α-crystallin domain protein in Arabidopsis. Mol Cell. 2014,55(3):361-71.

Lei M^#, La H^#, Lu K, Wang P, Miki D, Ren Z, Duan CG, Wang X, Tang K, Zeng L, Yang L, Zhang H, Nie W, Liu P, Zhou J, Liu R, Zhong Y, Liu D, Zhu JK^*. Arabidopsis EDM2 promotes IBM1 distal polyadenylation and regulates genome DNA methylation patterns. Proc Natl Acad Sci U S A. 2014,111(1):527-32.

Lei M^#, Liu D^*. Sucrose regulates plant responses to deficiencies in multiple nutrients. Plant Signal Behav. 2011,6(8):1247-9.

Lei M^#, Liu Y, Zhang B, Zhao Y, Wang X, Zhou Y, Raghothama KG, Liu D^*. Genetic and genomic evidence that sucrose is a global regulator of plant responses to phosphate starvation in Arabidopsis. Plant Physiol. 2011,156(3):1116-30.

Lei M^#, Zhu C, Liu Y, Karthikeyan AS, Bressan RA, Raghothama KG, Liu D^*. Ethylene signalling is involved in regulation of phosphate starvation-induced gene expression and production of acid phosphatases and anthocyanin in Arabidopsis. New Phytol. 2011,189(4):1084-95.