姓名: 王新泰，男，博士，副研究员，硕士生导师

办公电话：18368029687

邮箱：xintai@hznu.edu.cn

【研究领域】

遗传性小脑疾病的发育和功能缺陷的病理机制。

【主讲课程】

《基因工程实验》

【教育和工作经历】

2021/12-至今，杭州师范大学，生命与环境科学学院，副研究员

2019/5-2021/5，浙江大学，医学院，博士后

2015/9-2019/3，浙江大学，医学院，理学博士

2012/9-2015/6，兰州大学，药学院，医学硕士

2008/9-2012/6，中国海洋大学，医药学院，医学学士

【学术简介（限200字）】

主要从事于小脑相关疾病的发育和功能障碍的机制研究。综合利用转基因小鼠、人脑类器官培养、分子生化检测、全细胞膜片钳电生理记录、神经环路示踪以及动物行为学等实验技术，探究自闭症谱系障碍、小脑萎缩、运动障碍以及炎性疼痛等神经系统疾病发育和功能障碍的分子机制。以第一/共一/通讯作者的论文发表于Elife、Cell Reports、Journal of Physiology、Journal of Neuroscience、Pain等期刊，其他合作研究成果发表于Nature Neuroscience等期刊。

【主持教学科研项目】省部级以上

1. 国家自然科学基金青年基金，MeCP2调控小脑浦肯野细胞功能和运动与精神行为的研究，2021/1—2023/12，主持。

【代表性论著】

1. Wang XT, Zheng R, Dukhinova M, Wang L, Shen Y, Lin Z. Perspectives in the investigation of cockayne syndrome group b neurological disease: the utility of patient-derived brain organoid models. J ZHEJIANG UNIV-SC B. 2024. Accepted.

2. Wang XT¹, Zhou L¹, Xu FX, Wang DJ, Cai XY, Ma KY, Wang Q, Bao L, Ji SJ, Chris I. D Z, Shen Y. EPAC-PKC Module Induces Threonine Phosphorylation of RIM1 and Presynaptic Long-Term Potentiation. Elife. 2023 Apr 26;12:e80875.

3. Xu FX¹, Wang XT¹, Zhou L, Cai XY, Ma KY, Yang F, Martijn S, Chris I. D Z, Shen Y. Impaired motor learning and autistic-like behaviors following deletion of Mecp2 in Purkinje cells. Cell Rep. 2023 Dec 26;42(12):113559. (co-first author).

4. Wang XT, Shen Y. Plasticity of the Cerebellum. In: Gruol, D.L., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J.D., Shen, Y. (eds) Essentials of Cerebellum and Cerebellar Disorders. Springer, Cham. 2023.

5. Zheng R, Xu FX, Zhou L, Xu J, Shen Y, Hao K, Wang XT^#, Deng J^#. Ablation of KIF2C in Purkinje cells impairs metabotropic glutamate receptor trafficking and motor coordination in male mice. J Physiol. 2023 Sep;601(17):3905-3920. (co-corresponding author).

6. Zhou L, Wang K, Xu Y, Dong BB, Wu DC, Wang ZX, Wang XT, Cai XY, Yang JT, Zheng R, Chen W, Shen Y, Wei JS. A patient-derived mutation of epilepsy-linked LGI1 increases seizure susceptibility through regulating Kv1.1. Cell Biosci. 2023 Feb 20;13(1):34.

7. Zheng R¹, Du Y¹, Wang XT, Liao T, Zhang Z, Wang N, Li X, Shen Y, Shi L, Luo J, Xia J, Wang Z, Xu J. KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization. Elife. 2022 Feb 9;11:e72483.

8. Wang XT¹, Zhou L¹, Cai XY, Xu FX, Xu ZH, Li XY, Shen Y. Deletion of Mea6 in Cerebellar Granule Cells Impairs Synaptic Development and Motor Performance. Front Cell Dev Biol. 2021 Feb 25;8:627146.

9. Lyu C, Yu C, Sun G, Zhao Y, Cai R, Sun H, Wang XT, Jia G, Fan L, Chen X, Zhou L, Shen Y, Gao L, Li X. Deconstruction of Vermal Cerebellum in Ramp Locomotion in Mice. Adv Sci (Weinh). 2022 Nov 14;10(1):e2203665.

10. Wang N, Zhou L, Shao CY, Wang XT, Zhang N, Ma J, Hu HL, Wang Y, Qiu M, Shen Y. Potassium channel Kir 4.1 regulates oligodendrocyte differentiation via intracellular pH regulation. Glia. 2022 Nov;70(11):2093-2107.

11. Ma KY, Cai XY, Wang XT, Wang ZX, Huang WM, Wu ZY, Feng ZY, and Shen Y. Three-Dimensional Heterogeneity of Cerebellar Interposed Nucleus-Recipient Zones in the Thalamic Nuclei. Neurosci Bull. 2021 Nov;37(11):1529-1541.

12. Su LD, Xu FX, Wang XT, Cai XY, Shen Y. Cerebellar Dysfunction, Cerebro-cerebellar Connectivity and Autism Spectrum Disorders. Neuroscience. 2020 May 23(20):30323-30327.

13. Xu FX¹, Zhou L¹, Wang XT, Jia F, Ma KY, Wang N, Lin L, Xu FQ, Shen Y. Magneto is ineffective in controlling electrical properties of cerebellar Purkinje cells. Nat Neurosci. 2020 Sep 23(9):1041-1043.

14. Wang XT¹, Cai XY¹, Xu FX, Zhou L, Zheng R, Ma KY, Xu ZH, Shen Y. MEA6 Deficiency Impairs Cerebellar Development and Motor Performance by Tethering Protein Trafficking. Front Cell Neurosci. 2019; 13: 250.

15. Xie YJ¹, Zhou L¹, Wang Y, Jiang NW, Cao S, Shao CY, Wang XT, Li XY, Shen Y, Zhou L. Leucine-Rich Glioma Inactivated 1 Promotes Oligodendrocyte Differentiation and Myelination via TSC-mTOR Signaling. Front Mol Neurosci. 2018 Jul 6;11:231.

16. Zhou JH¹, Wang XT¹, Zhou L, Zhou L, Xu FX, Su LD, Wang H, Jia F, Xu FQ, Chen GQ, De Zeeuw CI, Shen Y. Ablation of TFR1 in Purkinje Cells Inhibits mGlu1 Trafficking and Impairs Motor Coordination, But Not Autistic-Like Behaviors. J Neurosci. 2017 Nov 22;37(47):11335-11352 (co-first author).

17. Wang XT¹, Zheng R¹, Suo ZW, Liu YN, Zhang ZY, Ma ZA, Xue Y, Xue M, Yang X, Hu XD. Activity-dependent dephosphorylation of paxillin contributed to nociceptive plasticity in spinal cord dorsal horn. Pain. 2016 Mar;157(3):652-665.

18. Lian X¹, Wang XT¹, Wang WT, Yang X, Suo ZW, Hu XD. Peripheral inflammation activated focal adhesion kinase signaling in spinal dorsal horn of mice. J Neurosci Res. 2015 Jun;93(6):873-81 (co-first author).

19. Xu YM¹, Wang XT¹, Zhang ZY, Suo ZW, Yang X, Hu XD. Noradrenergic α2 receptors attenuated inflammatory pain through STEP61/ERK signaling. Eur J Pain. 2015 Oct;19(9):1298-307. (co-first author).

20. Wang XT¹, Lian X¹, Xu YM, Suo ZW, Yang X, Hu XD. α2 noradrenergic receptor suppressed CaMKII signaling in spinal dorsal horn of mice with inflammatory pain. Eur J Pharmacol. 2014 Feb 5;724:16-23.