姓名: 沈晨佳

办公电话：13656676943

邮箱：shencj@hznu.edu.cn

【研究领域】

药用植物次生代谢调控；代谢相关基因克隆及功能研究。

【主讲课程】

《发育生物学》，《发育生物学实验》，《生命科学导论》，《分子生物学实验》，《药剂学》

【教育和工作经历】

2002.09-2006.06 青岛大学理工学院生物技术系本科，取得学士学位；

2006.09-2011.6浙江大学硕博连读，取得博士学位；

2011.09进入杭州师范大学生命与环境科学学院工作；

2012.3-2013.9于美国华盛顿州立大学高级访问学者。

【学术简介（限200字）】

长期以药用植物红豆杉、杭白菊等为研究对象，从事次生代谢调控及活性成分代谢相关基因研究。围绕红豆杉紫杉醇合成代谢通路，克隆相关基因及其调控因子，阐明紫杉醇合成调控的分子机制。以杭白菊、酸浆属植物为研究对象，探索环境胁迫下次生代谢产物积累的调控机制，研究人工诱导活性成分合成的技术途径。

【主持教学科研项目】

1. 国家自然科学基金面上项目《红豆杉紫杉烷类化合物雌雄株差异积累的分子机制研究》

2. 国家自然科学基金青年项目《水稻生长素响应因子 OsARF16 参与磷吸收调控的分子机制研究》

3. 浙江省自然科学基金一般项目《红豆杉雌雄株差异表达因子R2R3-MYB44和R2R3-MYB67参与紫杉醇合成的调控机制研究》

4. 浙江省自然科学基金一般项目《红豆杉内皮层特异表达RAV1因子参与紫杉醇合成调控机制研究》

5. 浙江省自然科学基金青年项目《OsARF16调控水稻耐低磷胁迫分子机制研究》

6. 杭州市科技局一般项目《苦職类黄酮合成关键基因克隆及应用》

【代表性论著】

(1) Shangguo Feng, Hou Kailin, Hongshan Zhang, Cheng Chen, Jiefang Huang, Qicong Wu, Zhenhao Zhang, Yadi Gao, Xiaomei Wu, Huizhong Wang, Chenjia Shen*; Investigation of the role of TmMYB16/123 and their targets (TmMTP1/11) in the tolerance of Taxus media to cadmium. Tree Physiol. 2023 Feb 20;tpad019.

(2)Yanjun Yang, Jie Liu, Taiyao Yi, Yao Li, Mengyuan Li, Haidi Liu, Lijun Zheng, Zhehao Chen, Juan Hao, Maojun Xu, Chenjia Shen*; Integrated mRNA and miRNA omics reveal the regulatory role of UV-B radiation in active ingredient biosynthesis of Chrysanthemum morifolium Ramat. Industrial Crops & Products 197 (2023) 116657.

(3) Lu Han, Xiaohua Wu, Kailin Hou, Hongshan Zhang, Xueshuang Liang, Cheng Chen, Zhijing Wang, Chenjia Shen*; Identification and functional analysis of calcium sensor calmodulins from heavy metal hyperaccumulator Noccaea caerulescens. Funct Plant Biol. 2023 Apr;50(4):294-302.

(4) Chunna Yu; Jiefang Huang; Qicong Wu; Chengchao Zhang; Xiao-lin Li; Xinyun Xu; Shangguo Feng; Xiaori Zhan; Zhehao Chen; Huizhong Wang; Chenjia Shen*; Role of female predominant MYB39-bHLH13 complex in sexually dimorphic accumulation of taxol in Taxus media. Hortic Res. 2022 Mar 14;9: uhac062.

(5) Xiaori Zhan, Zhehao Chen, Rong Chen, Chenjia Shen*; Environmental and genetic factors involved in plant protection-associated secondary metabolite biosynthesis pathways. Front Plant Sci. 2022 13:877304.

(6) Lu Han, Xiaohua Wu, Xinyu Zhang, Kailin Hou, Hongshan Zhang, Chenjia Shen*; Identification and functional analysis of cation-efflux transporter 1 from Brassica juncea L. BMC Plant Biol. 2022 22(1):174.

(7) Chunna Yu, Chengchao Zhang, Xinyun Xu, Jiefang Huang, Yueyue Chen, Xiujun Luo, Huizhong Wang, Chenjia Shen*; Omic analysis of the endangered Taxaceae species Pseudotaxus chienii revealed the differences in taxol biosynthesis pathway between Pseudotaxus and Taxus yunnanensis trees. BMC Plant Biol. 2021 21(1):104.

(8) Yanjun Yang, Jiena Guo, Jianmei Cheng, Zhifang Jiang, Ning Xu, Xinyan An, Zhehao Chen, Juan Hao , Siyu Yang, Zirui Xu, Chenjia Shen*, Maojun Xu; Identification of UV-B radiation responsive microRNAs and their target genes in chrysanthemum (Chrysanthemum morifolium Ramat) using high-throughput sequencing. Industrial Crops & Products 151 (2020) 112484.

(9) Chunna Yu, Xiujun Luo, Chengchao Zhang, Xinyun Xu, Jiefang Huang, Yueyue Chen, Shangguo Feng, Xiaori Zhan, Lei Zhang, Huwei Yuan, Bingsong Zheng, Huizhong Wang, Chenjia Shen*; Tissue-specific study across the stem of Taxus media identifies a phloem-specific TmMYB3 involved in the transcriptional regulation of paclitaxel biosynthesis. Plant J. 2020 103(1):95-110.

(10) Ting Zhou, Xiujun Luo, Chengchao Zhang, Xinyun Xu, Chunna Yu, Zhifang Jiang, Lei Zhang, Huwei Yuan, Bingsong Zheng, Erxu Pi, Chenjia Shen*; Comparative metabolomic analysis reveals the variations in taxoids and flavonoids among three Taxus species. BMC Plant Biol. 2019 19(1):529.

(11) Ting Zhou, Xiujun Luo, Chunna Yu, Chengchao Zhang, Lei Zhang, Yao-Bin Song, Ming Dong, Chenjia Shen*; Transcriptome analyses provide insights into the expression pattern and sequence similarity of several taxol biosynthesis-related genes in three Taxus species. BMC Plant Biol. 2019 19(1):33.

(12)Yanjun Yang, Zhifang Jiang, Jiena Guo, Xiuli Yang, Ning Xu, Zhehao Chen, Juan Hao, Jiaxun Li, Jiliang Pang, Chenjia Shen*, Maojun Xu; Transcriptomic analyses of Chrysanthemum morifolium Ramat under UV-B radiation treatment reveal variations in the metabolisms associated with bioactive components. Industrial Crops & Products 124 (2018) 475-486.

(13) Juan Hao, Kaili Jiao, Chenliang Yu, Hong Guo, Yujia Zhu, Xiao Yang, Siyang Zhang, Lei Zhang, Shangguo Feng, Yaobin Song, Ming Dong, Huizhong Wang, Chenjia Shen*; Development of SCoT-Based SCAR Marker for Rapid Authentication of Taxus Media. Biochem Genet. 2018 56(3):255-266.

(14) Xiaori Zhan, Xinyue Liao, Xiujun Luo, Yujia Zhu, Shangguo Feng, Chunna Yu, Jiangjie Lu, Chenjia Shen*, Huizhong Wang; Comparative Metabolomic and Proteomic Analyses Reveal the Regulation Mechanism Underlying MeJA-Induced Bioactive Compound Accumulation in Cutleaf Groundcherry (Physalis angulata L.) Hairy Roots. J. Agric. Food Chem. 2018, 66, 6336-6347.

(15) Juan Hao, Hong Guo, Xinai Shi, Ye Wang, Qinghua Wan, Yao-Bin Song, Lei Zhang, Ming Dong, Chenjia Shen*. Comparative proteomic analyses of two Taxus species (Taxus × media and Taxus mairei) reveals variations in the metabolisms associated with paclitaxel and other metabolites. Plant Cell Physiol. 2017, 1;58(11):1878-1890.

(16) Chunna Yu, Hong Guo, Yangyang Zhang, Yaobin Song, Erxu Pi, Chenliang Yu, Lei Zhang, Ming Dong, Bingsong Zheng, Huizhong Wang, Chenjia Shen*. Identification of potential genes that contributed to the variation in the taxoid contents between two Taxus species (Taxus media and Taxus mairei). Tree Physiol. 2017, 37(12):1659-1671.

(17) Shangguo Feng, Kaili Jiao, Hong Guo, Mengyi Jiang, Juan Hao, Huizhong Wang, Chenjia Shen*. Succinyl-proteome profiling of Dendrobium officinale, an important traditional Chinese orchid herb, revealed involvement of succinylation in the glycolysis pathway. BMC Genomics. 2017, 10;18(1):598.

(18) Chenjia Shen, Yanjun Yang, Kaidong Liu, Lei Zhang, Hong Guo, Tao Sun, Huizhong Wang; Involvement of endogenous salicylic acid in iron-deficiency responses in Arabidopsis. Journal of Experimental Botany. 2016 ,67(14):4179-93.

(19) Chenjia Shen, Yanjun Yang, Liqun Du, Huizhong Wang; Calmodulin-binding transcription activators and perspectives for applications in biotechnology. Appl Microbiol Biotechnol. 2015, 99(24):10379-85.

(20) Chenjia Shen, Suikang Wang, Saina Zhang, Yanxia Xu, Qian Qian, Yanhua Qi, DeAn Jiang; OsARF16, a transcription factor, is required for auxin and phosphate starvation response in rice (Oryza sativa L.). Plant Cell and Environment, 2013, 36(3): 607-620

【荣誉与奖励】

2017年成为浙江省生物学中青年学科带头人

【授权专利及转化】

1.沈晨佳, 冯尚国等。鉴别南方红豆杉幼苗的分子特异性标记引物及方法 (专利号201410808716.4)

2.沈晨佳, 冯尚国等。鉴别曼地亚红豆杉幼苗的核苷酸序列、分子探针和方法 (专利号201410808201.4)

3.沈晨佳, 姜艳等。红豆杉活性提取物的提取方法 (专利号201310098948.0)

4. 沈晨佳，冯尚国等。一种东北红豆杉的分子特异性标记引物及其鉴别方法 (ZL201910262162.5)

5. 沈晨佳，俞春娜等。区分密叶红豆杉和云南红豆杉的代谢标志物及其检测方 (ZL201910876537.7)

6. 沈晨佳，俞春娜等。一种用于区分白豆杉和云南红豆杉的代谢标志物及其检测方法 (ZL201910891564.1)

7. 沈晨佳，俞春娜等。一种用于区分曼地亚红豆杉和东北红豆杉的代谢标志物及其检测方法（ZL201910891849.5）

8 沈晨佳，俞春娜等。一种用于区分云南红豆杉和南方红豆杉的代谢标志物及其检测方法 (ZL201910891566.0)