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洪益国团队

来源 : 杭州师范大学生命与环境科学学院     作者 : 生科院     时间 : 2020-02-12     点击 : 1096

团队宗旨

立足于杭州师范大学植物RNA信号传导研究中心和浙江省药用植物生物技术国际合作基地,建立和促进国内外学术交流与科技合作,在模式植物、粮食作物、药用及观赏植物中探究RNA 信号传导、遗传和表观遗传、寄主-病原互作的分子机制;建立组学实验技术平台,用于基因组功能研究;研究成果应用和服务于社会发展。

负责人简介

洪益国教授受聘杭州师范大学高端人才岗位,20112月入职生命与环境科学学院,建立植物RNA信号研究中心。现任英国皇家生物学会会员 (Elected Fellow of the Royal Society of Biology)、英国华威大学访问教授、英国伍斯特大学访问教授;任UKRI Global Challenges Research Fund International Peer Review College成员、任UKRI Future Leaders Fellowships Panel College成员;任Functional & Integrative Genomics (Springer Nature) 编辑、任Journal of Horticulture Sciences and Biotechnology副主编、任Frontiers in Plant Sciences – RNA Signaling in PlantsSmall RNA in Plant-Microbe Interactions主编;担任英国BBSRCNERC、美国NSF、法国ANR、以色列NSF和中国NSFC等基金会项目评委;担任Nature Plants, Plant Journal, Trends in Plant Sciences, Plant Biotechnology Journal, Journal of Experimental Botany, Journal of General Virology, The Royal Society-B, New Phytologist, PNAS等杂志审稿人;担任法国Bordeaux大学、美国California-San Diego大学、中国科学院和英国Oxford大学等PhD学位和PI学术评定/评审人。

PNAS, eLife, Plant Physiology, Plant Cell, Plant Journal, Journal of Virology, PLoS Pathogens, Nature Genetics等杂志发表研究论文100余篇,出版编辑英文专著3部,国际专利4项,国际授权专利1项。

成员及研究方向

主要科研领域包括:植物基因沉默中RNA信号传导机制;DNA甲基化与去甲基化介导的植物抗病毒机制、番茄果实发育成熟的遗传与表观遗传调控机制;RNA/蛋白信号传导介导的植物(作物/模式植物/药用植物)生长发育调控机制;病毒介导的植物功能基因组研究方法。团队目前在职教工8人,硕士生14人,访问学者1人;国际专家兼职学术顾问5人。

陈微微副教授:番茄表观遗传研究

洪益国教授:植物RNA信号传导、植物病毒技术

赖童飞助理研究员:转录因子调控果实成熟的分子机制

秦诚副研究员:植物开花调控机制

施农农教授:病毒-植物相互分子和遗传机制

俞志明助理研究员:植物可移动RNA及其生物功能

章鹏程中级实验助理:植物抗类病毒机制

张弦讲师:病毒-植物相互分子和遗传机制、病毒介导的基因编辑技术

主要在研项目

Ø国家自然科学基金面上项目拟南芥FTBP1基因调控开花启始的分子机制研究2020 - 2023

Ø国家自然科学基金面上项目植物选择性甲基化调控双生病毒DNA复制分子机理的研究2019 - 2022

Ø科技部国家政府间国际科技创新合作重点专项子课题中欧果树苗木无病毒化合作研究-葡萄病毒2018 - 2021

Ø国家自然科学基金面上项目拟南芥FBP基因调控植物开花启始的分子机制研究2018 - 2021

Ø杭州师范大学科研重点培育工程项目中欧植物RNA信号传导国际科技平台合作基地(2018 - 2021

Ø浙江省国际科技合作基地药用植物生物技术2016 -

Ø科技部/农业部国家转基因生物新品种培育重大专项子课题基于植物病毒载体的新型、高效、快速的基因修饰技术2016 - 2020

国际合作和研究生培养

杭州师范大学-英国华威大学RNA信号联合实验室;杭州师范大学-法国波尔多大学双硕士学位项目(HZNU-UB Double MSc Programme)、杭州师范大学-英国伍斯特大学植物分子健康联合实验室联合PhD项目。所指导的研究生以第一作者发表SCI论文16余篇。已毕业硕士19人,去向岗位遍及国内外科研院校、生物公司等行业的知名企业,如深造进入法国波尔多大学、中国科学院遗传所、中国科学院植物所、就职于深圳华大基因公司等。

部分发表文章 2011 -

 

ØYao M, Chen W, Kong J, Zhang X, Shi N, Zhong S, Ma P, Gallusci P, Jackson S, Liu Y, Hong Y* (2020) METHYLTRANSFERASE1 and ripening modulate vivipary during tomato fruit development. Plant Physiology accepted.

ØYu Z, Cho SK, Zhang P, Hong Y*, Hannapel DJ* (2020) Utilizing Potato virus X to monitor RNA movement. Methods in Molecular Biology 10.1007/978-1-0716-0712-1

ØYuan C, Li H, Qin C, Zhang X, Chen Q, Zhang P, Xu X, He M, Zhang X-l, Tör M, Xue D, Wang H, Jackson S, He Y, Liu Y, Shi N, Hong Y* (2020) Foxtail mosaic virus-induced flowering assays in monocot crops. Journal of Experimental Botany 71: 3012-3023 (COVER & INSIGHT COMMENTARY; JOURNAL OF EXPERIMENTAL BOTANY, 71: 2839–2841).

ØWang J, Chen T, Han M, Qian L, Li J, Wu M, Han T, Cao J, Nagalakshmi U, Rathjen J, Hong Y, Liu Y (2020) Plant immune receptor Tm-22 requires NBS domain-mediated oligomerization of CC domain at plasma membrane for its activation. PLoS Pathogens 16: e1008475.

ØLai T, Wang X, Ye B, Jin M, Chen W, Wang Y, Zhou Y, Blank A, Gu M, Zhang P, Zhang X, Li C, Wang H, Liu Y, Gallusci P, Tor M, Hong Y* (2020) Molecular and functional characterization of SlSPL-CNR in tomato fruit ripening and cell death. Journal of Experimental Botany 71: 2995-3011.

ØIsmayil A, Yang M, Haxim Y, Wang Y, Li J, Han L, Wang Y, Zheng X, Wei X, Nagalakshmi U, Hong Y, Hanley-Bowdoin L, Liu Y (2020) Cotton leaf curl Multan viral betasatellite encoded βC1 induces autophagy by disrupting the interaction of autophagy-related protein 3 with Glyceraldehyde-3-Phosphate Dehydrogenases. Plant Cell 32: 1124–1135 (HIGHLIGHT PLANT CELL 32: 805–806).

ØZhang X, Kang L, Zhang Q, Meng Q, Pan Y, Yu Z, Shi N, Jackson S, Zhang X-l, Wang H, Tör M, Hong Y (2019) An RNAi suppressor activates in planta virus-mediated gene editing. Functional & Integrative Genomics DOI: 10.1007/s10142-019-00730-y.

ØWang Y, Wu Y, Gong Q, Ismayil A, Yuan Y, Lian B, Jia Q, Han M, Deng H, Hong Y, Hanley-Bowdoin L, Qi Y, and Liu Y (2019) Geminiviral V2 protein suppresses transcriptional gene silencing through interaction with AGO4. Journal of Virology 93: e01675-18.

ØZhang X, Lai T, Zhang P, Zhang X-l, Yuan C, Jin Z, Li H, Yu Z, Qin C, Tör M, Ma P, Cheng Q, Hong Y (2019) Revisiting mobile RNA silencing in plants. Plant Science 278: 113-117 (Invited Review).

ØBilir O, Telli O, Norman C, Budak H, Hong Y, Tor M (2019) Small RNA inhibits infection by downy mildew pathogen Hyaloperonospora arabidopsidis. Molecular Plant Pathology 20: 1523-1534.

ØChen W, Zhang X, Fan Y, Li B, Ryabov E, Shi N, Zhao M, Yu Z, Qin C, Zheng Q, Zhang P, Wang H, Jackson S, Cheng Q, Liu Y, Gallusci G, Hong Y (2018) A genetic network for systemic RNA silencing in plant. Plant Physiology 176: 2700-2719.

ØIsmayil A, Haxim Y, Wang Y, Li H, Qian L, Han T, Chen T, Jia Q, Zhu S, Deng H, Gorovits R, Hong Y,Liu Y (2018) Cotton Leaf Curl Multan Virus C4 protein suppresses both transcriptional and post transcriptional gene silencing by interacting with SAM synthetase. PLoS Pathogens 14: e1007282.

ØYu Z, Chen Q, Chen W, Zhang X, Mei F, Zhang P, Zhao M, Wang X, Shi N, Jackson S, Hong Y (2018) Multigene editing via CRISPR/Cas9 guided by a single-sgRNA seed in Arabidopsis. Journal of Integrative Plant Biology. 60: 376-381.

ØDevran Z, Kahveci E, Hong Y, Studholme DJ, Tör M (2018) Identifying molecular markers suitable for Frl selection in tomato breeding. Theoretical and Applied Genetics 131: 2099–2105.

ØChen W, Yu Z, Kong J, Wang H, Li Y, Zhao M, Wang X, Zheng Q, Shi N, Zhang P, Zhong S, Hunter P, Tör M, Hong Y (2018) Comparative WGBS identifies genes that influence non-ripe phenotype in tomato epimutant Colourless non-ripening. Science China Life Science 61: 244-252.

ØQin C, Li B, Fan Y, Zhang X, Yu Z, Ryabov E, Zhao M, Wang H, Shi N, Zhang P, Jackson S, Tor M, Cheng Q, Liu Y, Gallusci P, Hong Y (2017) Roles of Dicer-Like proteins 2 and 4 in intra- and intercellular Antiviral Silencing. Plant Physiology 174:1067-1081.

ØQin C, Chen W, Shen J, Cheng L, Akande F, Zhang K, Yuan C, Li C, Zhang P, Shi N, Cheng Q, Liu Y, Jackson S, Hong Y (2017) A virus-induced flowering assay for functional dissection and analysis of monocot and dicot FT genes. Plant Physiology 174: 875-885.

ØHaxim Y, Ismayil A, Jia Q, Wang Y, Zheng X, Chen T, Qian L, Liu N, Wang YW, Han S, Cheng J, Qi Y, Hong Y, Liu Y (2017) Autophagy functions as an antiviral mechanism against geminiviruses in plants. eLife 6: e23897.

ØChen T, Liu D, NiuX, Wang J, Qian L, Han L, Liu N, Zhao J, Hong Y, Liu Y (2017) Antiviral resistance protein Tm-22 functions on the plasma membrane. Plant Physiology 173: 2399-2410.

ØBoureau L, How Kit A, Teyssier E, Drevensek S, Rainieri M, Joubès J, Stammitti L, Pribat A, Bowler C, Hong Y, Gallusci P (2016) A Curly leaf homologue controls both vegetative and reproductive development of tomato plants. Plant Molecular Biology 90: 485-501.

ØZhao J, Zhang X, Hong Y, Liu Y (2016) Chloroplast in plant-virus interaction. Frontiers in Microbiology 7: 1565.

ØJia Q, Liu N, Xie K, DaiY Han S, Qian L, Wang Y, Zhao J, Gorovits R, Xie D, Hong Y, Liu Y (2016) CLCuMuB βC1 subverts ubiquitination by interacting with NbSKP1s to enhance geminivirus infection in Nicotiana benthamiana. PLoS Pathogens 12: e1005668.

ØLiu N, Xie K, Jia Qi, Zhao J, Chen T, Wei X, Diao X, Hong Y, Liu Y (2016) Foxtail mosaic virus-induced gene silencing in monocot plants. Plant Physiology 171: 1801-1807.

ØWang Y, Zheng X, Yu B, Han S, Guo J, Tang H, Yu AYL, Deng H, Hong Y, Liu Y (2015) Disruption of microtubules in plants suppresses macroautophagy and triggers start excess-associated chloroplast autophagy. Autophagy 11: 2259-2274.

ØLiu RE, How-Kit A, Stammitti L, Teyssier E, Rolin D, Bertrand A, Halle S, Liu M, Kong J, Wu C, Degraeve-Guibault C, Chapman N, Maucourt M, Hodgman C, Tost J, Bouzayen M, Hong Y, Seymour GB, Giovannoni J, Gallusci P (2015) A DEMETER-Like DNA demethylase governs tomato fruit ripening. Proceedings of the National Academy of Sciences USA. 112: 10804-10809.

ØChen W, Kong J, Lai T, Manning K, Wu C, Wang Y, Qin C, Li B, Yu Z, Zhang X, He M, Zhang P, Gu M, Yang X, Mahammed A, Li C, Osman T, Shi N, Wang H, Jackson S, Liu Y, Gallusci P, Hong Y (2015) Tuning LeSPL-CNR expression by SlymiR157 affects tomato fruit ripening. Scientific Reports 5: 7852.

ØChen W, Kong J, Qin C, Yu S, Tan J, Chen Y, Wu C, Wang H, Shi Y, Li C, Li B, Zhang P, Wang Y, Lai T, Yu Z, Zhang X, Shi N, Wang H, Osman T, Liu Y, Manning K, Jackson J, Rolin D, Zhong S, Seymour GB, Gallusci P, Hong Y (2015) Requirement of CHROMOMETHYLASE3 for somatic inheritance of the spontaneous tomato epimutation Colourless non-ripening. Scientific Reports 5: 9192.

ØHan S, Wang Y, Zheng X, Jia Q, Zhao J, Bai F, Hong Y, Liu Y (2015) Cytoplastic glyceraldehyde-3-phosphate dehydorgenases interact with ATG3 to negatively regulate autophagy and immunity in plants. Plant Cell 27: 1316-1331.

ØChen W, Zhang Q, Kong J, Hu F, Li B, Wu C, Qin C, Zhang P, Shi N, Hong Y (2015) MR VIGS: microRNA-based virus induced gene silencing in plants. Methods in Molecular Biology 1287: 147-157.

ØHong Y, Jackson S (2015) Floral induction and flower formation – the role and potential applications of miRNAs. Plant Biotechnology Journal 13: 282-292 (Invited Review).

ØLai T, Wang Y, Zhou T, Mei F, Zhang P, Zhou Y, Shi N, Hong Y (2015) Virus-induced LeSPL-CNR silencing inhibits fruit ripening in tomato. Journal of Agricultural Science 7: 184-195.

ØQin C, Zhang Q, He M, Kong J, Li B, Mohamad A, Chen W, Zhang P, Zhang X, Yu Z, Lai T, Shi N, Osman T, Hong Y (2015) Chapter 14 Virus Technology for functional genomics in plants. Page 229-236. In Applied Plant Genomics and Biotechnology (eds by Poltronieri P, Hong Y). Elsevier/Woodhead Publishing.

ØSha A, Zhao J, Yin K, Tang Y, Wang Y, Wei X, Hong Y, Liu Y (2014) Virus-based MicroRNA silencing in plants. Plant Physiology 164: 36-47.

ØKong J, Chen W, Sheng J, Qin C, Lai T, Zhang P, Wang Y, Wu C, Yang X, Hong Y (2013) Virus-induced gene complementation in tomato. Plant Signaling & Behavior 8: e27142.

ØLi B, Hu F, Zhang Q, Zhang X, Hong Y (2013) A cellular gene as a double surveillance agent for plant to combat pathogen. Plant Signaling & Behavior. 8: e26817.

ØDu Y, Zhao J, Chen T, Liu Q, Zhang H, Wang Y, Hong Y, Xiao F, Zhang L, Shen Q, Liu Y (2013) Type I J-Domain NbMIP1 Proteins Are Required for Both Tobacco Mosaic Virus Infection and Plant Innate Immunity. PLoS Pathogens 9: e1003659.

ØWang Y, Yu B, Zhao J, Guo J, Li Y, Han S, Huang L, Du Y, Hong Y, Tang D, Liu Y (2013) Autophagy contributes to leaf start degradation. Plant Cell 25: 1383-1399 (Faculty of 1000 biology).

ØZhao J, Liu Q, Zhang H, Jia Q, Hong Y, Liu Y (2013) RuBisCO small subunit is involved in Tobamovirus movement and Tm22-mediated extreme resistance. Plant Physiology 161: 374-383 (Faculty of 1000 biology).

ØZhou T, Zhang H, Lai T, Qin C, Shi N, Wang H, Jin M, Zhong S, Fan Z, Liu Y, Wu Z, Jackson S, Giovannoni J, Rolin D, Gallusci P, Hong Y (2012) Virus-induced gene complementation reveals a transcription factor network in modulation of tomato fruit ripening. Scientific Reports 2: 836.

ØQin C, Shi N, Gu M, Zhang H, Li B, Shen J, Mohammed A, Ryabov E, Li C, Wang H, Liu Y, Osman T, Vatish M, Hong Y (2012) Involvement of RDR6 in short-range intercellular RNA silencing in Nicotiana benthamiana. Scientific Reports 2: 467.

ØXu G, Li S, Xie K, Zhang Q, Wang Y, Tang Y, LiuD, Hong Y, He C, Liu Y (2012) Plant ERD2-like proteins function as ER luminal protein receptors and participate in programmed cell death duringinnate immunity. Plant Journal 72:57-69.

ØJackson S, Hong Y (2012) Systemic movement of FT mRNA and a possible role in floral induction. Frontiers in Plant Science. 3: 127 (Invited review).

ØLi C, Gu M, Shi N, Zhang H, Yang X,Osman T, Liu Y, Wang H, Vatish M, Jackson S, Hong Y (2011) Mobile FT mRNA contributes to the systemic florigen signalling in floral induction. Scientific Reports 1:73(Research highlight in Nature Middle East, doi:10.1038/nmiddleeast.2011.123).

ØBruce G, Gu M, Shi N, Liu Y, Hong Y (2011) Influence of retinoblastoma-related gene silencing on the initiation of DNA replication by African cassava mosaic virus Rep in cells of mature leaves in Nicotiana benthamiana plants. Virology Journal 8:561.

ØShi NN, Xu Y, Yang KF, Chen Y, Wang HZ, Xu XB, Hong Y (2011) Development of a sensitive diagnostic assay to detect Cymbidium mosaic and Odontoglossum ringspot viruses in members of the Orchidaceae. Journal of Horticultural Science & Biotechnology 86: 69-73.

 

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地址:杭州师范大学仓前校区慎园15号楼
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