发育生物学

赵晓枫

来源 : 学科科研与社会服务办     作者 :       时间 : 2017-03-13     点击 : 1750

赵晓枫,男,1980.06生,博士,副研究员,硕士研究生导师,杭州市131人才,杭州市高层次人才。一直从事中枢神经系统少突胶质细胞发育、髓鞘化及其相关疾病分子机制研究。研究结果不仅有助于我们更好地理解少突胶质细胞髓鞘形成过程及其分子调控,更为临床中脱髓鞘疾病的治疗提供重要的理论基础和分子手段。近年来在本领域高水平期刊DevelopmentGlia等上发表科研论文12篇,累计影响因子>30。主持国家自然科学青年基金项目1项和面上项目1项、浙江省自然科学基金一般项目1项、杭州市农业自主项目1项、杭州留学回国人员创新类项目1项,作为学术骨干参与973项目子课题1项及国家基金面上项目6项。

联系方式:zxf79@sina.com0571-28860500

研究工作经历(按时间倒排序)

    2015-今,杭州师范大学,生命与环境科学学院生物系,副研究员,硕士生导师

    2015/12-2016/12,美国Emory大学,医学院药学系,访问学者

  2010/09-2012/05,美国路易斯维尔大学,解剖科学与神经生物学系,博士后

  2007/07-2009/09,浙江大学,生物学博士后流动站,博士后

2002/09-2007/06浙江大学,动物科学学院动物科学系,博士

主持项目

1.     国家自然科学基金面上项目少突胶质细胞分化和髓鞘化过程中QKI转录上调及其同工蛋白QKI-6产生的分子机制和作用研究(项目编号3207096558万,2021.01.01-2024.12.31

2.     国家基金面上项目中枢神经系统髓鞘形成过程中基于Nkx2.2的转录及转录后调控研究(项目编号 3147195589万,2015.01.01-2018.12.31

3.     国家基金青年基金项目Nkx2.2对髓鞘基因表达的转录调控及其在髓鞘结构维持中的作用 (项目编号:3100048820万,2010.01.01-2013.12.31)

4.     浙江省自然科学基金一般项目TAPP1 在少突胶质细胞分化及髓鞘化过程中的作用研究(项目编号:Y17C090017, 10万,2017.01.01-2019.12.31

5.     杭州市科委农业自主项目抑制素基因免疫提高地方鸡种繁殖性能研究 (项目编号:20160432B0120万,2016.01.01-2018.12.31

6.     杭州市留学归国人员创新性项目 RNA结合蛋白QKI 促进髓鞘产生的分子机制及其相关药物应用研究 10 2018

参与项目

1.     国家973项目子课题 MDD突触传递与可塑性异常及分子机制 (项目编号:2013CB531303

2.     国家基金面上项目髓鞘形成过程中神经元与少突胶质细胞间相互作用的分子机制研究 (项目编号:31372150

3.     国家基金面上项目 Shp2在少突胶质细胞分化和髓鞘形成中的功能研究(项目编号:31071879

4.     国家基金青年基金项目受体酪氨酸磷酸酶D 在中枢神经系统髓鞘化中的功能研究(项目编号:31201697

5.     国家基金青年基金项目RiPS 细胞用于脊髓损伤髓鞘修复的研究(项目编号:81200961

6.     国家基金青年基金项目Wntless对少突胶质细胞的分化及髓鞘化的功能研究(项目编号:31101642

7.     国家基金青年基金项目Mir-219在少突神经胶质细胞分化中的功能研究(项目编号:31000945

8.     浙江省重大科技专项项目 iPS细胞自体移植治疗脊髓损伤小鼠的研究(项目编号:2011C13030

9.     浙江省自然基金重点项目miRNA 在星形胶质细胞发育中的调控作用(项目编号:Z2100730

科研论文:

1.     Ruyi Mei, Jiaying Fu, Chunxia Jiang, Junlin Yang, Kang Zheng, Aifen Yang, Mengsheng Qiu, Xiaofeng Zhao. TAPP1 Represses the Differentiation of Oligodendrocyte and its Deficiency Accelerates Myelin Regeneration after Demyelinating Injuries. Neurosci. Bull. 2020 Nov 15. doi: 10.1007/s12264-020-00609-0.

2.     Xinyu Liu, Conghui Li, Kang Zheng, Xiaofeng Zhao, Xiaofeng Xu, Aifen Yang, Min Yi, Huaping Tao, Binghua Xie, Mengsheng Qiu & Junlin Yang. Chromosomal aberration arises during somatic reprogramming to pluripotent stem cells. Cell Div. 2020 Nov 3;15(1):12. doi: 10.1186/s13008-020-00068-z.

3.     Xu YP, Wang LZ, Zhou YL, Xiao Y, Gu WB, Li B, Zhao XF, Dong WR, Shu MA. Identification and functional analysis of two interferon regulatory factor 3 genes and their involvement in antiviral immune responses in the Chinese giant salamander Andrias davidianus. Dev Comp Immunol. 2020 Sep;110:103710. doi: 10.1016/j.dci.2020.103710. Epub 2020 Apr 18. PMID: 32311388.

4.     Wang LZ, Xu YP, Zhou YL, Liu ZP, Li B, Gu WB, Zhao XF, Dong WR, Shu MA. The first evidence of four transcripts from two Interleukin 18 genes in animal and their involvement in immune responses in the largest amphibian Andrias davidianus. Dev Comp Immunol. 2020 May;106:103598. doi: 10.1016/j.dci.2019.103598. Epub 2019 Dec 24. PMID: 31881236.

5.     Chen X, Wang F, Gan J, Zhang Z, Liang X, Li T, Huang N, Zhao X, Mei F, Xiao L. Myelin Deficits Caused by Olig2 Deficiency Lead to Cognitive Dysfunction and Increase Vulnerability to Social Withdrawal in Adult Mice. Neurosci Bull. 2020 Apr;36(4):419-426. doi: 10.1007/s12264-019-00449-7. Epub 2019 Nov 22. PMID: 31758330; PMCID: PMC7142181.

6.     Wan Y, Liu X, Zheng D, Wang Y, Chen H, Zhao X, Liang G, Yu D, Gan L. Systematic identification of intergenic long-noncoding RNAs in mouse retinas using full-length isoform sequencing. BMC Genomics. 2019 Jul 8;20(1):559. doi: 10.1186/s12864-019-5903-y. PMID: 31286854; PMCID: PMC6615288.

7.     Zheng K, Wang C, Yang J, Huang H, Zhao X, Zhang Z, Qiu M. Molecular and Genetic Evidence for the PDGFRα-Independent Population of Oligodendrocyte Progenitor Cells in the Developing Mouse Brain. J Neurosci. 2018 Oct 31;38(44):9505-9513. doi: 10.1523/JNEUROSCI.1510-18.2018. Epub 2018 Sep 21. PMID: 30242047; PMCID: PMC6705995.

8.     Jiang C, Yang W, Fan Z, Teng P, Mei R, Yang J, Yang A, Qiu M, Zhao X. AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination. Neurosci Bull. 2018 Jun;34(3):527-533. doi: 10.1007/s12264-018-0218-6. Epub 2018 Mar 19. PMID: 29556912; PMCID: PMC5960454.

9.     Chen X, Ku L, Mei R, Liu G, Xu C, Wen Z, Zhao X, Wang F, Xiao L, Feng Y. Novel schizophrenia risk factor pathways regulate FEZ1 to advance oligodendroglia development. Transl Psychiatry. 2017 Dec 18;7(12):1293. doi: 10.1038/s41398-017-0028-z. PMID: 29249816; PMCID: PMC5802537.

10. Huang H, Teng P, Mei R, Yang A, Zhang Z, Zhao X, Qiu M. Tmeff2 is expressed in differentiating oligodendrocytes but dispensable for their differentiation in vivo. Sci Rep. 2017 Mar 23;7(1):337. doi: 10.1038/s41598-017-00407-1. PMID: 28336932; PMCID: PMC5428413.

11. Cheng X, Xie B, Qi J, Zhao X, Zhang Z, Qiu M, Yang J. Rat astrocytes are more supportive for mouse OPC self-renewal than mouse astrocytes in culture. Dev Neurobiol. 2017 Sep;77(8):907-916. doi: 10.1002/dneu.22476. Epub 2017 Mar 23. PMID: 28033654.

12. Yang J, Cheng X, Shen J, Xie B, Zhao X, Zhang Z, Cao Q, Shen Y, Qiu M. A Novel Approach for Amplification and Purification of Mouse Oligodendrocyte Progenitor Cells. Front Cell Neurosci. 2016 Aug 22;10:203. doi: 10.3389/fncel.2016.00203. PMID: 27597818; PMCID: PMC4992724.

13. Zhu Q, Tan Z, Zhao S, Huang H, Zhao X, Hu X, Zhang Y, Shields CB, Uetani N, Qiu M. Developmental expression and function analysis of protein tyrosine phosphatase receptor type D in oligodendrocyte myelination. Neuroscience. 2015 Nov 12;308:106-14. doi: 10.1016/j.neuroscience.2015.08.062. Epub 2015 Sep 1. PMID: 26341907; PMCID: PMC4600676.

14. Chen Y, Mei R, Teng P, Yang A, Hu X, Zhang Z, Qiu M, Zhao X. TAPP1 inhibits the differentiation of oligodendrocyte precursor cells via suppressing the Mek/Erk pathway. Neurosci Bull. 2015 Oct;31(5):517-26. doi: 10.1007/s12264-015-1537-5. Epub 2015 Aug 4. PMID: 26242484; PMCID: PMC5563677.

15. Zhao X, Chen Y, Zhu Q, Huang H, Teng P, Zheng K, Hu X, Xie B, Zhang Z, Sander M, Qiu M. Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor. PLoS One. 2014 Oct 6;9(10):e109171. doi: 10.1371/journal.pone.0109171. PMID: 25285789; PMCID:PMC4186865.

16. Zhao X, Huang H, Chen Y, Liu Y, Zhang Z, Ma Q, Qiu M. Dynamic expression of secreted Frizzled-related protein 3 (sFRP3) in the developing mouse spinal cord and dorsal root ganglia. Neuroscience. 2013 Sep 17;248:594-601. doi: 10.1016/j.neuroscience.2013.06.044. Epub 2013 Jul 1. PMID: 23827310; PMCID: PMC3844105.

17. Huang H, Zhao XF, Zheng K, Qiu M. Regulation of the timing of oligodendrocyte differentiation: mechanisms and perspectives. Neurosci Bull. 2013 Apr;29(2):155-64. doi: 10.1007/s12264-013-1314-2. Epub 2013 Feb 28. PMID: 23456566; PMCID: PMC3761796.

18. Zhu Q, Whittemore SR, Devries WH, Zhao X, Kuypers NJ, Qiu M*. Dorsally-derived oligodendrocytes in the spinal cord contribute to axonal myelination during development and remyelination following focal demyelination. Glia, 59(11), 1612-1621. 2011.


联系我们

地址:杭州师范大学仓前校区慎园15号楼
邮编:311121
电话:0571-28865333
本科招生热线:0571-28865326
研究生招生热线:0571-28861205

关注我们
学院团委微信
Copyright © 2020 杭州师范大学生命与环境科学学院      

Copyright © 2020 All Rights Reserved
地址:杭州师范大学仓前校区慎园15号楼
邮编:311121 电话:0571-28865333
浙ICP备11056902号
版权所有 © 杭州师范大学生命与环境科学学院
技术支持:亿校云