课题组简介：

课题组现有教师3人，其中教授1人，副教授1人，讲师1人。

本课题组以模式植物拟南芥、农作物水稻和大豆、以及新兴作物藜麦为研究对象，利用遗传学、生化和分子生物学、表观遗传学等手段研究信号感知、信号传递和信号途径的调控网络，挖掘作物营养高效和耐逆的遗传位点，并利用基因编辑等生物育种手段提高作物的产量、品质和耐逆性。

课题组主持多个国家级、省部级科研项目，并获得国家和学校人才项目的支持，取得了一系列国际领先的研究成果。以第一作者或通讯作者在Nature Plants、Nature Communications、Molecular Plant、Molecular Cell、PNAS等国际重要学术期刊上发表了多篇高水平学术论文。

课题组负责人：雷明光

课题组成员

教师：董劲松、马国杰

博士后：葛圣红

学生：吕秋雨、向宇丹、谭诗美、李威、倪晓丽、卢宪伟、陈浩

访问学生：孟凡孝、李小强、Abdul Wahab、张珂、肖梦岚、邓孟磊

主要研究方向

植物分子营养学：研究植物磷信号感受机制、信号转导和调控网络，以及植物低磷响应的表观遗传学机制，挖掘优异基因资源，培育磷高效吸收和利用的农作物。

农作物生物育种：开发基因编辑新技术和新方法，创制农作物新种质，提高农作物的产量和品质、抗逆性和资源利用效率

代表性论著（#一作，*通讯作者）

1. Dong C., Xi Y., Satheesh V., Lei M*. Advances in CRISPR/Cas technologies and their application in plants. Tropical Plants 2023, 2:2

2. Satheesh V., Wahab A., Ramakrishnan M., Lei M^*. Molecular Mechanisms Underlying Phosphate Sensing and Signalling in Plants. In: Rouached, H., & B. Satbhai, S. (eds) Plant Phosphorus Nutrition (1st ed.). CRC Press. 2023, 18-29

3. Zhou X, Wei M, Nie W, Xi Y, Li P, Zheng Q, Tang K, Satheesh V, Wang Y, Luo J, Du X, Liu R, Yang Z, La H, Zhong Y, Yang Y, Zhu JK, Du J, Lei M*. The H3K9me2-binding protein AGDP3 limits DNA methylation and transcriptional gene silencing in Arabidopsis. J Integr Plant Biol. 2022, 64(12):2385-2395.

4. Xiao X, Zhang J, Satheesh V, Meng F, Gao W, Dong J, Zheng Z, An GY, Nussaume L, Liu D, Lei M*. SHORT-ROOT stabilizes PHOSPHATE1 to regulate phosphate allocation in Arabidopsis. Nat Plants. 2022, 8:1074–1081

Ma G, Satheesh V, Lei M*. Intracellular phosphate sensing in plants. Mol Plant. 2022 Dec 5;15(12):1831-1833.

5. Li T, Zhang R, Satheesh V, Wang P, Ma G, Guo J, An GY, Lei M*. The Chromatin Remodeler BRAHMA Recruits HISTONE DEACETYLASE6 to Regulate Root Growth Inhibition in Response to Phosphate Starvation in Arabidopsis. J Integr Plant Biol. 2022, 64(12):2314-2326

6. Xiao X, Meng F, Satheesh V, Xi Y, Lei M*. An Agrobacterium-mediated transient expression method contributes to functional analysis of a transcription factor and potential application of gene editing in Chenopodium quinoa. Plant Cell Rep. 2022, 41:1975-1985.

7. Satheesh V^#, Zhang J^#, Li J, You Q, Zhao P, Wang P, Lei M*. High transcriptome plasticity drives phosphate starvation responses in tomato. Stress Biology, 2022, 2:18.

8. Satheesh V^#, Tahir A, Li J, Lei M*. Plant phosphate nutrition: sensing the stress. Stress Biology, 2022, 2:16。

9. Zhou J^#, Hu Q^#, Xiao X, Yao D, Ge S, Ye J, Li H, Cai R, Liu R, Meng F, Wang C, Zhu JK, Lei M^*, Xing W^*. Mechanism of phosphate sensing and signaling revealed by rice SPX1-PHR2 complex structure. Nat Commun, 2021, 12:7040

10. Satheesh V., Li J., Lei M^*. Efficient CRISPR-Cas9-Mediated Genome Editing in Tomato. In: Islam M.T., Molla K.A. (eds) CRISPR-Cas Methods. Springer Protocols Handbooks. Humana, New York, NY. 2021, 159-177

11. Satheesh V., Wahab A., Ramakrishnan M., Lei M^*. Molecular Mechanisms Underlying Phosphate Sensing and Signalling in Plants. In: Rouached, H., & B. Satbhai, S. (eds) Plant Phosphorus Nutrition (1st ed.). CRC Press. 2023, 18-29

12. Dong J^#, Ma G^#, Sui L^#, Wei M, Satheesh V, Zhang R, Ge S, Li J, Zhang TE, Wittwer C, Jessen HJ, Zhang H, An GY, Chao DY, Liu D, Lei M^*. Inositol Pyrophosphate InsP8 Acts as an Intracellular Phosphate Signal in Arabidopsis. Mol Plant. 2019, 12:1463-1473

13. Nie WF^#, Lei M^#, Zhang M, Tang K, Huang H, Zhang C, Miki D, Liu P, Yang Y, Wang X, Zhang H, Lang Z, Liu N, Xu X, Yelagandula R, Zhang H, Wang Z, Chai X, Andreucci A, Yu JQ, Berger F, Lozano-Duran R, Zhu JK^*. Histone acetylation recruits the SWR1 complex to regulate active DNA demethylation in Arabidopsis. Proc Natl Acad Sci U S A. 2019, 116(33):16641-16650.

14. Satheesh V^#, Zhang H, Wang X, Lei M^*. Precise editing of plant genomes – Prospects and challenges. Semin Cell Dev Biol. 2019, 96:115-123

15. Xiao X^#, Zhang J, Li T, Fu X, Satheesh V, Niu Q, Lang Z, Zhu JK^*, Lei M^*. A group of SUVH methyl-DNA binding proteins regulate expression of the DNA demethylase ROS1 in Arabidopsis. J Integr Plant Biol. 2019,61(2):110-119.

16. Zhao P^*, You Q, Lei M^*. A CRISPR/Cas9 deletion into the phosphate transporter SlPHO1;1 reveals its role in phosphate nutrition of tomato seedlings. Physiol Plant. 2019, 167(4):556-563.

17. Lei M^#, Zhang H, Julian R, Tang K, Xie S, Zhu JK^*. Regulatory link between DNA methylation and active demethylation in Arabidopsis. Proc Natl Acad Sci U S A. 2015,112(11):3553-7.

18. Lang Z^#, Lei M^#, Wang X, Tang K, Miki D, Zhang H, Mangrauthia SK, Liu W, Nie W, Ma G, Yan J, Duan CG, Hsu CC, Wang C, Tao WA, Gong Z, Zhu JK^*. The methyl-CpG-binding protein MBD7 facilitates active DNA demethylation to limit DNA hyper-methylation and transcriptional gene silencing. Mol Cell. 2015,57(6):971-983.

19. Qian W^#, Miki D^#, Lei M^#, Zhu X, Zhang H, Liu Y, Li Y, Lang Z, Wang J, Tang K, Liu R, Zhu JK^*. Regulation of active DNA demethylation by an α-crystallin domain protein in Arabidopsis. Mol Cell. 2014,55(3):361-71.

20. Lei M^#, La H^#, Lu K, Wang P, Miki D, Ren Z, Duan CG, Wang X, Tang K, Zeng L, Yang L, Zhang H, Nie W, Liu P, Zhou J, Liu R, Zhong Y, Liu D, Zhu JK^*. Arabidopsis EDM2 promotes IBM1 distal polyadenylation and regulates genome DNA methylation patterns. Proc Natl Acad Sci U S A. 2014,111(1):527-32.

21. Lei M^#, Liu D^*. Sucrose regulates plant responses to deficiencies in multiple nutrients. Plant Signal Behav. 2011,6(8):1247-9.

22. Lei M^#, Liu Y, Zhang B, Zhao Y, Wang X, Zhou Y, Raghothama KG, Liu D^*. Genetic and genomic evidence that sucrose is a global regulator of plant responses to phosphate starvation in Arabidopsis. Plant Physiol. 2011,156(3):1116-30.

23. Lei M^#, Zhu C, Liu Y, Karthikeyan AS, Bressan RA, Raghothama KG, Liu D^*. Ethylene signalling is involved in regulation of phosphate starvation-induced gene expression and production of acid phosphatases and anthocyanin in Arabidopsis. New Phytol. 2011,189(4):1084-95.