博士，教授，生物与医药专业硕士研究生导师，杭州市131人才，杭州市高层次人才。一直从事中枢神经系统胶质细胞发育及其相关疾病分子机制研究，近年着重研究方向：1.重塑肠道菌群及其代谢物调控中枢髓鞘修复的机制研究；2.新材料在肿瘤细胞治疗中的作用及机制研究；3.儿童难治性癫痫的致病机理及治疗策略研究。研究结果不仅有助于理解细胞发育涉及的分子调控网络，更为临床中相关疾病的治疗提供相关的理论基础和新策略。

在本领域高水平期刊发表科研论文多篇，并作为多家SCI杂志审稿专家，国家自然科学基金项目评审专家，浙江省自然科学基金评审专家，广东省自然科学基金省外评审专家。主持国家自然科学基金项目4项、浙江省自然科学基金一般项目1项、杭州留学回国人员创新类项目1项，作为学术骨干参与科技部科技创新2030-“脑科学与类脑研究”重大专项。

联系方式：xfzhao@hznu.edu.cn，0571-28860500

研究工作经历

2015-今，杭州师范大学，生命与环境科学学院生物系，副教授，硕士生导师

2015/12-2016/12，美国Emory大学，医学院药学系，访问学者

2010/09-2012/05，美国路易斯维尔大学，解剖科学与神经生物学系，博士后

2007/07-2009/09，浙江大学，生物学博士后流动站，博士后

2002/09-2007/06，浙江大学，动物科学学院动物科学系，博士

主持项目

1. 国家自然科学基金面上项目少突胶质细胞对海马脑区苔藓纤维出芽的影响及其对癫痫发生的作用研究（项目编号32471022，50万，2025.01.01-2028.12.31）

2.    国家自然科学基金面上项目少突胶质细胞分化和髓鞘化过程中QKI转录上调及其同工蛋白QKI-6产生的分子机制和作用研究（项目编号32070965，58万，2021.01.01-2024.12.31）

3.    国家基金面上项目中枢神经系统髓鞘形成过程中基于Nkx2.2的转录及转录后调控研究（项目编号 31471955，89万，2015.01.01-2018.12.31）

4.    国家基金青年基金项目Nkx2.2对髓鞘基因表达的转录调控及其在髓鞘结构维持中的作用 (项目编号：31000488，20万，2010.01.01-2013.12.31)

5.    浙江省自然科学基金一般项目TAPP1 在少突胶质细胞分化及髓鞘化过程中的作用研究（项目编号：Y17C090017, 10万，2017.01.01-2019.12.31）

近五年发表文章

1: Jiang C, Hu Y, Zhang F, Qiu M, Zhao X. Hippocampal Oligodendrocytes Regulate Mossy Fiber Development Involved in Epileptic Responses. Neurosci Bull. 2025 Jul 17. doi: 10.1007/s12264-025-01452-x. Epub ahead of print. PMID: 40673958.

2: Jiang J, Sun Y, Ma Y, Xu C, Zhao X, Fu H. Advances in Therapeutics Research for Demyelinating Diseases. Pharmaceuticals (Basel). 2025 Dec 1;18(12):1835. doi: 10.3390/ph18121835. PMID: 41471322; PMCID: PMC12736135.

3: Jiang C, Qiu W, Yang Y, Huang H, Dai ZM, Yang A, Tang T, Zhao X, Qiu M. ADAMTS4 Enhances Oligodendrocyte Differentiation and Remyelination by Cleaving NG2 Proteoglycan and Attenuating PDGFRα Signaling. J Neurosci. 2023 Jun 14;43(24):4405-4417. doi: 10.1523/JNEUROSCI.2146-22.2023. Epub 2023 May 15. PMID: 37188512; PMCID: PMC10278682.

4: Yu D, Wu Y, Zhu L, Wang Y, Sheng D, Zhao X, Liang G, Gan L. The landscape of the long non-coding RNAs in developing mouse retinas. BMC Genomics. 2023 May 10;24(1):252. doi: 10.1186/s12864-023-09354-w. PMID: 37165305; PMCID:PMC10173636.

5: Mei R, Qiu W, Yang Y, Xu S, Rao Y, Li Q, Luo Y, Huang H, Yang A, Tao H, Qiu M, Zhao X. Evidence That DDR1 Promotes Oligodendrocyte Differentiation during Development and Myelin Repair after Injury. Int J Mol Sci. 2023 Jun 19;24(12):10318. doi: 10.3390/ijms241210318. PMID: 37373466; PMCID: PMC10299687.

6: Wu XQ, Fu JY, Mei RY, Dai XJ, Li JH, Zhao XF, Liu MQ. Inhibition of Liver Cancer HepG2 Cell Proliferation by Enzymatically Prepared Low-molecular Citrus Pectin. Curr Pharm Biotechnol. 2022;23(6):861-872. doi:10.2174/1389201022666210729122631. PMID: 34376132.

7: Mei R, Fu J, Jiang C, Yang J, Zheng K, Yang A, Qiu M, Zhao X. TAPP1 Represses the Differentiation of Oligodendrocyte and its Deficiency Accelerates Myelin Regeneration after Demyelinating Injuries. Neurosci Bull. 2021 Mar;37(3):385-388. doi: 10.1007/s12264-020-00609-0. Epub 2020 Nov 15. PMID:33190191; PMCID: PMC7955016.

8: Su D, Jiang Z, Xu Y, Li J, Qi Q, Gong Y, Wang H, Zhao Z, Zhao X, Zhou J. Molecular design of ternary copolymers with high photothermal performance in the near-infrared window for effective treatment of gliomas in vivo. Acta Biomater. 2025 Jan 15;192:302-314. doi: 9.1016/j.actbio.2024.12.025. Epub 2024 Dec 12.PMID: 39674238.

9: Yao H, Meng T, Yang Y, Tao H, Lu W, Liu M, Zhao X, Qiu M, Yang A. Identification of Methylstat as a Potential Therapeutic Agent for Human Glioma Cells by Targeting Cell Cycle Arrest. Pharmaceuticals (Basel). 2025 Sep 8;18(9):1344. doi: 10.3390/ph18091344. PMID: 41011214; PMCID: PMC12472336.

10: Wen J, Wu Y, Zhang F, Wang Y, Yang A, Lu W, Zhao X, Tao H. Neonatal hypoxia leads to impaired intestinal function and changes in the composition and metabolism of its microbiota. Sci Rep. 2025 May 1;15(1):15285. doi:10.1038/s41598-025-00041-2. PMID: 40312410; PMCID: PMC12045951.

11: Ju J, Yang X, Jiang J, Wang D, Zhang Y, Zhao X, Fang X, Liao H, Zheng L, Li S, Hou ST, Liang L, Pan Y, Li H, Li N. Structural and Lipidomic Alterations of Striatal Myelin in 16p11.2 Deletion Mouse Model of Autism Spectrum Disorder. Front Cell Neurosci. 2021 Aug 12;15:718720. doi: 10.3389/fncel.2021.718720. PMID: 34483844; PMCID: PMC8416256.

12: Chen X, Wang F, Gan J, Zhang Z, Liang X, Li T, Huang N, Zhao X, Mei F, Xiao L. Myelin Deficits Caused by Olig2 Deficiency Lead to Cognitive Dysfunction and Increase Vulnerability to Social Withdrawal in Adult Mice. Neurosci Bull. 2020 Apr;36(4):419-426. doi: 10.1007/s12264-019-00449-7. Epub 2019 Nov 22. PMID: 31758330; PMCID: PMC7142181.

13: Qi Q, Jiang Z, Li J, Wei H, Su D, Gong Y, Wang H, Zhao Z, Zhao X, Zhou J. Ternary Copolymers Incorporating Tunable Conjugated Donors for Near-Infrared II Fluorescence Imaging and Photothermal Therapy. Adv Healthc Mater. 2025 Jul;14(19):e2500966. doi: 10.1002/adhm.202500966. Epub 2025 Jun 2. PMID:40457652.

14: Wei H, Wang H, Gong Y, Yao H, Qi Q, Wang T, Li W, Li J, Zhao X, Zhou J. A dual-drug delivery hydrogel platform based on hollow calcium carbonate nanoparticles for enhanced multimodal tumor therapy. J Colloid Interface Sci. 2026 Feb;703(Pt 1):139110. doi: 10.1016/j.jcis.2025.139110. Epub 2025 Sep 25. PMID: 41016107.

15: Mei R, Huang L, Wu M, Jiang C, Yang A, Tao H, Zheng K, Yang J, Shen W, Chen X, Zhao X, Qiu M. Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers. Front Cell Neurosci. 2021 Sep 22;15:751439. doi: 10.3389/fncel.2021.751439. PMID: 34630045; PMCID:PMC8492996.